Short-term Mortality Outcomes of HIV-Associated Cryptococcal Meningitis in Antiretroviral Therapy-Naïve and -Experienced Patients in Sub-Saharan Africa.
Short-term Mortality Outcomes of HIV-Associated Cryptococcal Meningitis in Antiretroviral Therapy-Naïve and -Experienced Patients in Sub-Saharan Africa.
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在撒哈拉以南非洲的抗逆转录病毒治疗和经验丰富的患者中，与HIV相关的隐球菌脑膜炎的短期死亡率结果。
DOI：
10.1093/ofid/ofab397
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发表时间：
2021-10
影响因子：
4.2
通讯作者：
Molloy SF
中科院分区：
文献类型：
--
作者：
Kalata N;Ellis J;Kanyama C;Kuoanfank C;Temfack E;Mfinanga S;Lesikari S;Chanda D;Lakhi S;Nyazika T;Chan AK;van Oosterhout JJ;Chen T;Hosseinipour MC;Lortholary O;Wang D;Jaffar S;Loyse A;Heyderman RS;Harrison TS;Molloy SF
An increasing proportion of patients with HIV-associated cryptococcal meningitis have received antiretroviral therapy (ART) before presentation. There is some evidence suggesting an increased 2-week mortality in those receiving ART for <14 days compared with those on ART for >14 days. However, presentation and outcomes for cryptococcal meningitis patients who have recently initiated ART, and those with virologic failure and/or nonadherence, are not well described. Six hundred seventy-eight adults with a first episode of cryptococcal meningitis recruited into a randomized, noninferiority, multicenter phase 3 trial in 4 Sub-Saharan countries were analyzed to compare clinical presentation and 2- and 10-week mortality outcomes between ART-naïve and -experienced patients and between patients receiving ART for varying durations before presentation. Over half (56%; 381/678) the study participants diagnosed with a first episode of cryptococcal meningitis were ART-experienced. All-cause mortality was similar at 2 weeks (17% vs 20%; hazard ratio [HR], 0.85; 95% CI, 0.6–1.2; P = .35) and 10 weeks (38% vs 36%; HR, 1.03; 95% CI, 0.8–1.32; P = .82) for ART-experienced and ART-naïve patients. Among ART-experienced patients, using different cutoff points for ART duration, there were no significant differences in 2- and 10-week mortality based on duration of ART. In this study, there were no significant differences in mortality at 2 and 10 weeks between ART-naïve and -experienced patients and between ART-experienced patients according to duration on ART.
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影响因子：
168.9
作者：
Brouwer, AE;Rajanuwong, A;Harrison, TS
通讯作者：
Harrison, TS
影响因子：
4.2
作者：
Ellis, Jayne;Bangdiwala, Ananta S.;Boulware, David R.
通讯作者：
Boulware, David R.
影响因子：
56.3
作者：
Rhein, Joshua;Hullsiek, Kathy Huppler;Nielsen, Kirsten
通讯作者：
Nielsen, Kirsten
DOI：
10.1056/nejmoa1312884
发表时间：
2014-06-26
期刊：
The New England journal of medicine
影响因子：
--
作者：
Boulware DR;Meya DB;Muzoora C;Rolfes MA;Huppler Hullsiek K;Musubire A;Taseera K;Nabeta HW;Schutz C;Williams DA;Rajasingham R;Rhein J;Thienemann F;Lo MW;Nielsen K;Bergemann TL;Kambugu A;Manabe YC;Janoff EN;Bohjanen PR;Meintjes G;COAT Trial Team
通讯作者：
COAT Trial Team
影响因子：
3.8
作者：
Alufandika, Melanie;Lawrence, David S.;Jarvis, Joseph N.
通讯作者：
Jarvis, Joseph N.