INFLUENCE OF SLEEP ON LUNG-VOLUME IN ASTHMATIC-PATIENTS AND NORMAL SUBJECTS
INFLUENCE OF SLEEP ON LUNG-VOLUME IN ASTHMATIC-PATIENTS AND NORMAL SUBJECTS
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DOI：
10.1152/jappl.1990.68.5.2034
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发表时间：
1990-05-01
影响因子：
3.3
通讯作者：
WHITE, DP
中科院分区：
文献类型：
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作者：
BALLARD, RD;IRVIN, CG;WHITE, DP
为了评估睡眠对正常受试者和哮喘患者的功能残气量 (FRC) 的影响，使用水平体积位移身体体积描记器对 10 名成年受试者（5 名夜间恶化的哮喘患者，5 名正常对照）进行过夜监测。通过使用单一吸气闭塞技术，我们确定当仰卧和清醒时，哮喘患者相对于正常对照过度充气（FRC 分别 = 3.46 .+-. 0.18 和 2.95 .+-. 0.13 升；P < 0.05）。睡眠期间，两组的 FRC 均下降，但哮喘患者的下降幅度明显更大，因此在快速眼动 (REM) 睡眠期间，哮喘组和正常组的 FRC 相当（FRC 分别 = 2.46 .+-. 0.23 和 2.45 .+-. 0.09 升）。哮喘患者的比肺电导率在夜间逐渐显着下降，从0.047.+-下降。 0.007 至 0.018.+-。 0.002 cmH2O-1 .cntdot。 s-1（P < 0.01）。在 5 名哮喘患者中，只有 2 名患者的 FRC 与肺电导之间在夜间存在显着的线性关系（分别为 r = 0.55 和 0.65）。我们得出的结论是：1）正常受试者和哮喘患者的 FRC 在睡眠期间都会下降，2）在清醒哮喘患者中观察到的过度充气在非快速眼动睡眠期间减少，并在快速眼动睡眠期间消除，3）与睡眠相关的 FRC 降低可能有助于但不能解释在夜间恶化的哮喘患者中观察到的所有夜间气流阻力增加。
To assess the effect of sleep on functional residual capacity (FRC) in normal subjects and asthmatic patients, 10 adult subjects (5 asthmatic patients with nocturnal worsening, 5 normal controls) were monitored overnight in a horizontal volume-displacement body plethysmograph. With the use of a single inspiratory occlusion technique, we determined that when supine and awake, asthmatic patients were hyperinflated relative to normal controls (FRC = 3.46 .+-. 0.18 and 2.95 .+-. 0.13 liters, respectively; P < 0.05). During sleep FRC decreased in both groups, but the decrease was significantly greater in asthmatic patients such that during rapid-eye-movement (REM) sleep FRC was equivalent between the asthmatic and normal groups (FRC = 2.46 .+-. 0.23 and 2.45 .+-. 0.09 liters, respectively). Specific pulmonary conductance decreased progressively and significantly in the asthmatic patients during the night, falling from 0.047 .+-. 0.007 to 0.018 .+-. 0.002 cmH2O-1 .cntdot. s-1 (P < 0.01). There was a significant linear relationship through the night between FRC and pulmonary conductance in only two of the five asthmatic patients (r = 0.55 and 0.65, respectively). We conclude that 1) FRC falls during sleep in both normal subjects and asthmatic patients, 2) the hyperinflation observed in awake asthmatic patients is diminished during non-REM sleep and eliminated during REM sleep, and 3) sleep-associated reductions in FRC may contribute to but do not account for all the nocturnal increase in airflow resistance observed in asthmatic patients with nocturnal worsening.