Microbial control of arthropod-borne disease.
Microbial control of arthropod-borne disease.
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DOI：
10.1590/0074-02760160373
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发表时间：
2017-02
影响因子：
2.8
通讯作者：
Hughes GL
中科院分区：
文献类型：
--
作者：
Saldaña MA;Hegde S;Hughes GL
节肢动物体内有各种各样的微生物，这些微生物深刻地影响着寄主生物学的许多方面，包括媒介能力。此外，共生体可以被改造成产生抑制病原体的分子。由于它们与宿主的密切联系，微生物已经开发出促进它们水平或垂直传播到同种生物的策略。这些属性使微生物成为控制节肢动物传播疾病的应用策略的诱导剂。在这里，我们讨论微生物控制方法的最新进展，以减少寨卡病毒、登革热和基孔肯雅病毒以及锥虫和疟原虫等病原体的负担。我们还强调需要进一步调查的地方。
Arthropods harbor a diverse array of microbes that profoundly influence many aspects of host biology, including vector competence. Additionally, symbionts can be engineered to produce molecules that inhibit pathogens. Due to their intimate association with the host, microbes have developed strategies that facilitate their transmission, either horizontally or vertically, to conspecifics. These attributes make microbes attractive agents for applied strategies to control arthropod-borne disease. Here we discuss the recent advances in microbial control approaches to reduce the burden of pathogens such as Zika, Dengue and Chikungunya viruses, and Trypanosome and Plasmodium parasites. We also highlight where further investigation is warranted.