Impulsive Choice in Mice Lacking Paternal Expression of Grb10 Suggests Intragenomic Conflict in Behavior.
Impulsive Choice in Mice Lacking Paternal Expression of Grb10 Suggests Intragenomic Conflict in Behavior.
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DOI：
10.1534/genetics.118.300898
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发表时间：
2018-05
期刊：
影响因子：
3.3
通讯作者：
Isles AR
中科院分区：
文献类型：
--
作者：
Dent CL;Humby T;Lewis K;Ward A;Fischer-Colbrie R;Wilkinson LS;Wilkins JF;Isles AR
印记基因Grb10仅在父亲的大脑中表达。在这里，登特等人表明，父亲Grb 10调节冲动的选择，即动物是否选择较小的食物奖励。印记基因仅作为发生在哺乳动物生殖系中的表观遗传事件的结果从一个亲本等位基因表达，并且被认为是通过亲本等位基因之间的基因组内冲突进化的。我们证明，第一次，对大脑和行为的印记基因的对立影响。具体来说，我们发现，缺乏父亲Grb10的小鼠做出更少的冲动选择，对冲动行为的单独测量没有可分离的影响。结合先前的研究表明，缺乏母体Nesp55的小鼠会做出更多冲动的选择，这表明冲动的选择行为是基因组印记作用的底物。此外，这两个基因的对比效应表明，冲动的选择受到基因组内冲突的影响，母亲和父亲的利益将这种行为推向相反的方向。最后，这些数据也可能表明，印记基因表达的不平衡导致了赌博和吸毒成瘾等病理状态，其中冲动行为变得适应不良。
The imprinted gene Grb10 is expressed in the brain from the paternal copy only. Here, Dent et al. show that paternal Grb10 regulates impulsive choices, i.e. whether an animal chooses a smaller food reward... Imprinted genes are expressed from one parental allele only as a consequence of epigenetic events that take place in the mammalian germ line and are thought to have evolved through intragenomic conflict between parental alleles. We demonstrate, for the first time, oppositional effects of imprinted genes on brain and behavior. Specifically, we show that mice lacking paternal Grb10 make fewer impulsive choices, with no dissociable effects on a separate measure of impulsive action. Taken together with previous work showing that mice lacking maternal Nesp55 make more impulsive choices, this suggests that impulsive choice behavior is a substrate for the action of genomic imprinting. Moreover, the contrasting effect of these two genes suggests that impulsive choices are subject to intragenomic conflict and that maternal and paternal interests pull this behavior in opposite directions. Finally, these data may also indicate that an imbalance in expression of imprinted genes contributes to pathological conditions such as gambling and drug addiction, where impulsive behavior becomes maladaptive.