The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop
The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop
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DOI：
10.1093/gerona/glx090
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发表时间：
2017-11-01
影响因子：
5.1
通讯作者：
Thannickal, Victor J.
中科院分区：
文献类型：
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作者：
Budinger, G. R. Scott;Kohanski, Ronald A.;Thannickal, Victor J.
在过去的十年中，慢性肺病的死亡人数正在增加，慢性阻塞性肺病已成为美国第三大死亡原因。慢性和急性肺部疾病对老年人的影响尤为严重，随着全球人口老龄化，这些疾病可能会变得更加频繁和严重。慢性肺部疾病与大量的发病率相关，经常导致运动限制性呼吸困难、固定和隔离。因此，预防或治疗肺部疾病的有效策略可能会延长健康寿命和寿命。这篇综述总结了NIA和NHLBI联合举办的研讨会的结果，该研讨会汇集了专注于衰老和肺生物学的研究人员。这些研究人员鼓励在肺病研究中使用遗传系统和老年动物，并开发基于综合系统的平台，该平台可以动态地整合描述健康和疾病中老化肺的基因组学、转录组学、表观基因组学、代谢组学和蛋白质组学的数据集。建议开展进一步研究，将肺部老化的基准生物学标志与具有不同病理的急性和慢性肺部疾病的病理生物学结合起来，其中高龄是最重要的风险因素。
Death from chronic lung disease is increasing and chronic obstructive pulmonary disease has become the third leading cause of death in the United States in the past decade. Both chronic and acute lung diseases disproportionately affect elderly individuals, making it likely that these diseases will become more frequent and severe as the worldwide population ages. Chronic lung diseases are associated with substantial morbidity, frequently resulting in exercise limiting dyspnea, immobilization, and isolation. Therefore, effective strategies to prevent or treat lung disease are likely to increase healthspan as well as life span. This review summarizes the findings of a joint workshop sponsored by the NIA and NHLBI that brought together investigators focused on aging and lung biology. These investigators encouraged the use of genetic systems and aged animals in the study of lung disease and the development of integrative systems- based platforms that can dynamically incorporate data sets that describe the genomics, transcriptomics, epigenomics, metabolomics, and proteomics of the aging lung in health and disease. Further research was recommended to integrate benchmark biological hallmarks of aging in the lung with the pathobiology of acute and chronic lung diseases with divergent pathologies for which advanced age is the most important risk factor.