Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction
Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction
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DOI：
10.3171/2011.8.focus11182
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发表时间：
2011-11-01
影响因子：
4.1
通讯作者：
Messerer, Mahmoud
中科院分区：
文献类型：
--
作者：
Dubourg, Julie;Messerer, Mahmoud
创伤性脑损伤（TBI）被认为是垂体功能低下的一个原因，即使在轻度的TBI之后。尽管在过去的十年中，越来越多的研究详细描述了创伤性脑损伤引起的神经内分泌变化，但导致这种垂体功能障碍的机制和危险因素仍不清楚。在世界各地，体育运动——尤其是格斗运动——非常受欢迎。然而，在大多数流行病学研究中，运动通常不被认为是TBI的原因，直到最近才对运动相关的头部创伤和垂体功能减退之间的联系进行了调查。因此，缺乏关于这一重要问题的数据。由于大量年轻的运动参与者的预期寿命接近正常，未确诊或未经治疗的脑震荡后垂体功能障碍的影响可能是巨大的。因此，了解运动损伤引起垂体功能减退的病理生理机制和危险因素是医务人员和体育赞助商关注的一个重要问题。本文的目的是总结理解病理生理机制的最佳证据，并讨论目前有关运动相关头部创伤作为垂体功能减退的原因的数据和建议。(DOI: 10.3171 / 2011.8.focus11182)
Traumatic brain injury (TBI) is recognized as a cause of hypopituitarism even after mild TBI. Although over the past decade, a growing body of research has detailed neuroendocrine changes induced by TBI, the mechanisms and risk factors responsible for this pituitary dysfunction are still unclear. Around the world, sports-especially combative sports-are very popular. However, sports are not generally considered as a cause of TBI in most epidemiological studies, and the link between sports-related head trauma and hypopituitarism has not been investigated until recently. Thus, there is a paucity of data regarding this important concern. Because of the large number of young sports participants with near-normal life expectancy, the implications of undiagnosed or untreated postconcussion pituitary dysfunction can be dramatic. Understanding the pathophysiological mechanisms and risk factors of hypopituitarism caused by sports injuries is thus an important issue that concerns both medical staff and sponsors of sports. The aim of this paper was to summarize the best evidence for understanding the pathophysiological mechanisms and to discuss the current data and recommendations on sports-related head trauma as a cause of hypopituitarism. (DOI: 10.3171/2011.8.FOCUS11182)