Molecular pathogenesis and prognostication of "low-grade'' and "high-grade" endometrial stromal sarcoma.
Molecular pathogenesis and prognostication of "low-grade'' and "high-grade" endometrial stromal sarcoma.
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DOI：
10.1002/gcc.22907
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Panagopoulos I
中科院分区：
文献类型：
--
作者：
Micci F;Heim S;Panagopoulos I
子宫内膜间质肉瘤（ESS）是一组罕见的间叶细胞癌的异质性。近年来，人们对这些癌症的分子特征有了相当多的了解，这有助于以更有意义的方式对它们进行分类，从而改善诊断、诊断和治疗。根据这一分类，ESS现在被分为低级或高级。ESS可能有重叠的临床表现，形态学和免疫组化特征。它们的遗传特征允许根据它们携带的致病性重要融合基因对它们中的许多进行细分，但显然在这方面需要解开更多的谜团。我们在这里提供了一个概述的分子病理学知识，迄今为止获得的低级别和高级别ESS。
Endometrial stromal sarcomas (ESS) are a heterogeneous group of rare mesenchymal cancers. Considerable knowledge has been gained in recent years about the molecular characteristics of these cancers, which helps to classify them in a more meaningful manner leading to improved diagnosis, prognostication, and treatment. According to this classification, ESS is now grouped as low‐ or high‐grade. ESS may have overlapping clinical presentation, morphology, and immunohistochemical profile. Their genetic characteristics allow subdivision of many of them depending on which pathogenetically important fusion genes they carry, but clearly much more needs to be unraveled in this regard. We here provide an overview of the molecular pathogenetic knowledge gained so far on low‐ and high‐grade ESS.
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DOI：
10.1097/pas.0000000000000721
发表时间：
2017-01
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Hoang LN;Aneja A;Conlon N;Delair DF;Middha S;Benayed R;Hensley ML;Park KJ;Hollmann TJ;Hameed MR;Antonescu CR;Soslow RA;Chiang S
通讯作者：
Chiang S
影响因子：
5.6
作者：
Chiang, Sarah;Ali, Rola;Oliva, Esther
通讯作者：
Oliva, Esther
影响因子：
6.4
作者：
Dewaele, Barbara;Przybyl, Joanna;Debiec-Rychter, Maria
通讯作者：
Debiec-Rychter, Maria
影响因子：
4.7
作者：
Amant, Frederic;Woestenborghs, Heidi;Vergote, Ignace
通讯作者：
Vergote, Ignace
影响因子：
--
作者：
Astolfi, Annalisa;Melchionda, Fraia;Pession, Andrea
通讯作者：
Pession, Andrea