PORTABLE GAMMA PROBE FOR RADIOIMMUNE LOCALIZATION OF EXPERIMENTAL COLON-TUMOR XENOGRAFTS
PORTABLE GAMMA PROBE FOR RADIOIMMUNE LOCALIZATION OF EXPERIMENTAL COLON-TUMOR XENOGRAFTS
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DOI：
10.1016/0022-4804(84)90130-6
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发表时间：
1984-01-01
影响因子：
2.2
通讯作者：
MARTIN, EW
中科院分区：
文献类型：
--
作者：
AITKEN, DR;THURSTON, MO;MARTIN, EW
目前实施的肿瘤放射免疫检测利用伽马闪烁照相机对肿瘤成像。一个主要的临床限制是无法检测小于2 cm的肿瘤。这种限制部分是由于平方反比定律，该定律指出：检测到的放射性计数的数量与放射源与检测设备之间的距离的平方成反比。研制了一种适合术中使用的手持式γ探测探头（GDP）。GDP可以放置在放射性肿瘤附近，并以外部扫描相机不可能的方式利用平方反比定律。放射性标记的狒狒癌胚抗原（CEA）特异性抗血清的使用增加了肿瘤同位素定位在CEA生产的肿瘤相比，注射非特异性抗血清。肿瘤同位素-抗血清定位不受肿瘤体积或肿瘤植入后时间的影响。GDP探针计数显示与伽马孔组织计数高度相关。该探针能够以低于外部闪烁照相机可以检测到的剂量检测优先肿瘤定位。
Tumor radioimmune detection as presently practiced utilizes a gamma scintillation camera to image tumors. A major clinical limitation is the inability to detect tumors smaller than 2 cm. This limitation is due in part to the inverse square law which states: the number of detected radioactive counts is inversely proportional to the square of the distance separating a radioactive source from the detecting device. A hand-held gamma-detecting probe (GDP) suitable for intraoperative use has been developed. The GDP can be placed near radioactive tumors and take advantage of the inverse square law in a way not possible with external scanning cameras. The use of radiolabeled baboon carcinoembryonic antigen (CEA)-specific antisera produced increased tumor isotope localization in CEA-producing tumors compared to the injection of nonspecific antisera. Tumor isotope-antisera localization was not influenced by tumor volume or time since tumor implantation. The GDP probe counts demonstrated a high degree of correlation with gamma well tissue counts. The probe was able to detect preferential tumor localization in doses lower than could be detected with external scintillation cameras.