Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan
Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan
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DOI：
10.5588/ijtld.10.0679
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发表时间：
2011-11-01
影响因子：
4
通讯作者：
Khan, A. J.
中科院分区：
文献类型：
--
作者：
Qazi, F.;Khan, U.;Khan, A. J.
培养转化是治疗耐多药结核病(MDR-TB)的临时监测工具。我们评估了参加巴基斯坦卡拉奇印度河医院基于社区的耐多药结核病管理计划的肺多药耐药结核病患者的培养转化时间和预测因素。尽管每天严格的直接观察治疗，每月的食物奖励和患者咨询，培养转化的中位时间总结为196天(范围32-471)。培养2个月、4个月、6个月和12个月的累计转化率分别为6%、33%、47%和73%。吸烟、基线涂片等级高以及以前使用二线药物会推迟培养转化。
Culture conversion is an interim monitoring tool for treatment of multidrug-resistant tuberculosis (MDR-TB). We evaluated the time to and predictors of culture conversion in pulmonary MDR-TB patients enrolled in the community-based MDR-TB management program at the Indus Hospital in Karachi, Pakistan. Despite strict daily directly observed therapy, monthly food incentives and patient counseling, the median time to culture conversion SUMMARY was 196 days (range 32-471). The cumulative probabilities of culture conversion by 2, 4, 6 and 12 months were respectively 6%, 33%, 47%, and 73%. Smoking, high smear grade at baseline and previous use of second-line drugs delayed culture conversion.