Blink Reflex Recovery after Electrical Stimulation of the Reinnervated Orbicularis Oculi Muscle in Dogs
Blink Reflex Recovery after Electrical Stimulation of the Reinnervated Orbicularis Oculi Muscle in Dogs
复制标题
电刺激犬神经重新支配的眼轮匝肌后眨眼反射的恢复
DOI：
--
复制
发表时间：
1990
影响因子：
1.5
通讯作者：
B. Stromberg
中科院分区：
文献类型：
--
作者：
G. Salerno;J. N. Bleicher;B. Stromberg
麻痹性兔眼症伴随着眼睑神经断伤和随后的眼轮匝肌周围去神经支配，通常与暴露的角膜的有害影响有关。本研究探讨了日常电刺激如何影响这肌肉的眨眼反射恢复后，其神经再支配。6只狗进行了单侧面神经断伤，立即修复眼睑神经。随机选择3只狗接受电刺激再神经支配的眼轮匝肌75天。其余3只犬为对照组（未刺激肌肉）。实验过程中观察了眼轮匝肌电生理和瞬目反射的恢复情况。使用Student t检验进行统计分析。结果可归纳如下：（1）在30 ~ 50天，刺激肌肉引起上睑完全闭合的最小平均刺激强度显著低于未刺激肌肉（2）刺激后睑裂完全闭合（眨眼反射）在49.6天，显著早于（p < 0.01）未刺激肌肉（72.6天）。它的结论是，每日电刺激眼轮匝肌，如果立即开始后，神经外膜修复的眼睑神经neurotmesis，促进更快的眨眼反射恢复在狗模型。
The paralytic lagophthalmos following palpebral nerve neurotmesis and consequent peripheral denervation of the orbicularis oculi muscle is often associated with harmful effects on the exposed cornea. This study investigated how daily electrical stimulation affects the blink reflex recovery of this muscle after its reinnervation. Six dogs underwent unilateral facial nerve neurotmesis with immediate epineurial repair of the palpebral nerve. Three dogs were randomly chosen to receive electrical stimulation of the reinnervated orbicularis oculi muscles for 75 days. The remaining 3 dogs were controls (nonstimulated muscles). During the study, the reinnervated orbicularis oculi muscle electrophysiology and blink reflex recovery were investigated. The Student's t test was used for statistical analysis. The results can be summarized as follows: (1) between 30 and 50 days, the minimum mean stimulus intensities evoking complete upper palpebral closure of the stimulated muscles were significantly lower than those of the nonstimulated muscles (p < 0.01) and (2) the stimulated muscles recovered complete closure of the interpalpebral fissure (blink reflex) at 49.6 days, significantly earlier (p < 0.01) than the nonstimulated muscles (72.6 days). It is concluded that daily electrical stimulation of the orbicularis oculi muscles, if started immediately after epineurial repair of the palpebral nerve neurotmesis, promotes a faster blink reflex recovery in the dog model.