Compound IMM‐H004, a Novel Coumarin Derivative, Protects against CA1 Cell Loss and Spatial Learning Impairments Resulting from Transient Global Ischemia
Compound IMM‐H004, a Novel Coumarin Derivative, Protects against CA1 Cell Loss and Spatial Learning Impairments Resulting from Transient Global Ischemia
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DOI：
10.1111/cns.12364
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发表时间：
2015-03
影响因子：
5.5
通讯作者：
W. Zuo;Wei Zhang;Ning Han;N. Chen
中科院分区：
文献类型：
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作者：
W. Zuo;Wei Zhang;Ning Han;N. Chen
化合物IMM-H004（7-羟基-5-甲氧基-4-甲基-3-[4-甲基哌嗪-1-基]-2H-苯并吡喃-2-酮）是一种新型的香豆素合成衍生物，前期研究表明其在局灶性脑缺血中具有抗氧化和神经保护作用。然而，我们对该化合物在短暂性全身缺血中的功能知之甚少。本研究旨在探讨化合物 IMM-H004 是否可以预防短暂性全身缺血性损伤。
Compound IMM‐H004 (7‐hydroxy‐5‐methoxy‐4‐methyl‐3‐[4‐methylpiperazin‐1‐yl]‐2H‐chromen‐2‐one) is a new synthetic derivative of coumarin, and previous studies showed that it exhibited antioxidant and neuroprotective roles in focal cerebral ischemia. However, we know little about the compound's function in transient global ischemia. This study is to investigate whether compound IMM‐H004 can protect against transient global ischemic injury.