What determines blood viscosity at the highest city in the world?
What determines blood viscosity at the highest city in the world?
复制标题
世界最高城市的血液粘度由什么决定？
DOI：
10.1113/jp280206
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Williams,AlexanderT
中科院分区：
文献类型：
--
作者：
Cabrales,Pedro;Govender,Krianthan;Williams,AlexanderT
生活在高海拔地区的个体容易受到大气氧（O2）张力（PO2）降低的影响，从而导致肺泡PO2降低、动脉PO2降低和向组织输送氧气受限。在某些情况下，对长期暴露于高海拔的不适应补偿导致慢性山地综合征（CMS），甚至对那些原生于高海拔地区的人也是如此。有限的动脉氧饱和度和缺氧驱动红细胞生成系统过度的红细胞增多，导致总血红蛋白（Hb）、红细胞（RBC）计数和红细胞压积（Hct）增加。患有CMS的人还可能出现肺动脉高压、睡眠障碍、头痛、耳鸣和其他临床症状。到目前为止，大多数研究都表明CMS的临床症状源于Hct增加导致的血液粘度增加，但Stauffer等人在本期《生理学杂志》上发表的一篇题为《世界上最高城市的血液粘度及其决定因素》的研究提供的证据表明，高原红细胞增多症本身并不能充分解释CMS个体发生的血液流变学变化
Individuals who live at high elevation are subject to reduced atmospheric oxygen (O2) tension (PO2), leading to decreased alveolar PO2, reduced arterial PO2, and limited O2 delivery to tissues. In some cases, maladaptive compensation for chronic exposure to high altitude leads to chronic mountain syndrome (CMS) even for individuals who are native to high altitudes. Limited arterial O2 saturation and hypoxia drive the erythropoietic system to excessive erythrocytosis, resulting in increased total haemoglobin (Hb), red blood cell (RBC) count, and haematocrit (Hct). Individuals with CMS can also develop pulmonary hypertension, sleep disturbances, headaches, tinnitus, and other clinical symptoms. Most of the studies until now have suggested that the clinical symptoms of CMS stem from the increase in blood viscosity resulting from increased Hct, but evidence presented in a study published in this issue of The Journal of Physiology by Stauffer et al., titled Blood viscosity and its determinants in the highest city in the world shows that high altitude polycythaemia alone does not sufficiently explain the haemorheological changes occurring in CMS individuals