METHODS FOR COMBINING RANDOMIZED CLINICAL-TRIALS - STRENGTHS AND LIMITATIONS
METHODS FOR COMBINING RANDOMIZED CLINICAL-TRIALS - STRENGTHS AND LIMITATIONS
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DOI：
10.1002/sim.4780060325
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发表时间：
1987-04-01
影响因子：
2
通讯作者：
DEMETS, DL
中科院分区：
文献类型：
--
作者：
DEMETS, DL
从几项研究中合并数据的方法存在，似乎是非常有用的。没有一项研究令人满意地解决了应该合并哪些研究的问题。这个问题是最严重的方法限制。即使是具有统计学显著性相互作用的研究，如果影响方向相同，也可以合并。因此，需要大量的科学投入，以确定每项可能的研究必须符合哪些标准。通过组合或汇集数据可以学到很多东西，但必须谨慎行事。合并试验不能取代设计良好的前瞻性临床试验。努力制定基本设计标准，使多中心和多国试验更容易结合起来，可能是有益的。
Methods for combining data from several studies exist and appear to be quite useful. None satisfactorily addresses the question of what studies should be combined. This issue is the most serious methodological limitation. Even studies with statistically significant interaction might still be combined if the effect were in the same direction. Thus, substantial scientific input is required as to what criteria must be met by each potential study. Much can be learned from combining or pooling data but it must be done cautiously. Pooling exercises do not replace well designed prospective clinical trials. Efforts for establishing basic design criteria to allow for multicentre and multicountry trials to be more easily combined might be useful.