Effects of preloads of water and saline on thermal dehydration-induced thirst.
Effects of preloads of water and saline on thermal dehydration-induced thirst.
复制标题
水和盐水预负荷对热脱水引起的口渴的影响。
DOI：
10.1016/s0031-9384(96)00533-1
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发表时间：
1997
影响因子：
2.9
通讯作者：
Barney,CC
中科院分区：
文献类型：
--
作者：
Barney,CC
巴尼角C.水和盐预负荷对热脱水诱导口渴的影响。《物理学》第五卷第61卷第5期第763-769页，1997年。在雄性Sprague-Dawley大鼠暴露于40°C环境4小时后，研究了细胞和细胞外水分不足对热脱水引起口渴的相对作用。胃内（IG）和静脉内（IV）预负荷水降低升高的血浆钠和血浆渗透压热脱水大鼠的控制水平，但预负荷的盐水没有。IG和IV预负荷的生理盐水返回热脱水大鼠的红细胞压积和血浆蛋白浓度的控制水平。IG水预加载和IG盐水预加载都减少了水的摄入量，其中IG水预加载具有更大的效果。IV水预负荷将水摄入量减少到接近对照水平，而IV盐水预负荷对水摄入量没有影响。这些数据表明，热脱水大鼠的水摄入量主要是由于细胞水分不足，口服和胃因素也很重要，在终止热脱水大鼠的水摄入量。
BARNEY, C. C. Effects of preloads of water and saline on thermal dehydration-induced thirst. PHYSIOL BEHAV 61(5) 763–769, 1997.—The relative contribution of cellular and extracellular water deficits to the genesis of thirst due to thermal dehydration was studied in male Sprague-Dawley rats following exposure to a 40°C environment for 4 h. Intragastric (IG) and intravenous (IV) preloads of water reduced the elevated plasma sodium and plasma osmolality of thermally dehydrated rats to control levels, but preloads of saline did not. IG and IV preloads of saline returned the hematocrit and plasma protein concentration of thermally dehydrated rats to control levels. Both the IG water preload and the IG saline preload reduced water intake, with the IG water preload having a greater effect. The IV water preload reduced water intake nearly to control levels, whereas the IV saline preload was without effect on water intake. These data indicate that the water intake of thermally dehydrated rats is primarily due to a cellular water deficit and that oral and gastric factors are also important in terminating water intake in thermally dehydrated rats.