Involvement of H2O2 production in cisplatin-induced nephrotoxicity.
Involvement of H2O2 production in cisplatin-induced nephrotoxicity.
复制标题
H2O2 的产生参与顺铂诱导的肾毒性。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
Mineo Niwa
中科院分区：
文献类型：
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作者：
Yasuyuki Tsutsumishita;Tomoaki Onda;Kaname Okada;M. Takeda;Hitoshi Endou;Shiroh Futaki;Mineo Niwa
本研究的目的是阐明H2O2的产生参与顺铂诱导的肾毒性。S3细胞在顺铂处理期间的细胞活力和H2O2产生方面比OMCT细胞更敏感。顺铂诱导的细胞毒性和H2O2的产生被过氧化氢酶处理终止。总之，我们强调羟基自由基在顺铂肾毒性中的重要性。
The purpose of this study was to elucidate the involvement of H2O2 production in cisplatin-induced nephrotoxicity. The S3 cells were more sensitive than OMCT cells in cell viability and H2O2 production during cisplatin treatment. The cytotoxicity and H2O2 production induced by cisplatin were terminated by treatment with catalase. In conclusion, we emphasize the importance of the hydroxy radical in cisplatin nephrotoxicity.