Updated survival analysis of two sequential prospective trials of R-MACLO-IVAM followed by maintenance for newly diagnosed mantle cell lymphoma.
Updated survival analysis of two sequential prospective trials of R-MACLO-IVAM followed by maintenance for newly diagnosed mantle cell lymphoma.
复制标题
DOI：
10.1002/ajh.23996
复制
发表时间：
2015-06
影响因子：
12.8
通讯作者：
Lossos, Izidore S.
中科院分区：
文献类型：
--
作者：
Hosein, Peter J.;Sandoval-Sus, Jose D.;Goodman, Deborah;Arteaga, Alexandra Gomez;Reis, Isildinha;Hoffman, James;Stefanovic, Alexandra;Rosenblatt, Joseph D.;Lossos, Izidore S.
A phase II trial of R-MACLO-IVAM followed by thalidomide maintenance for mantle cell lymphoma (MCL) demonstrated promising progression-free survival (PFS) and overall survival (OS) rates. Thalidomide maintenance was associated with significant toxicity and was subsequently modified to rituximab maintenance. Herein we present updated results and follow-up. Two sequential phase II trials included chemotherapy-naïve patients with MCL up to 75 years old. Four cycles of R-MACLO-IVAM chemotherapy were delivered as previously described. Patients who achieved complete responses (CR) were eligible for thalidomide or rituximab maintenance therapy. Among 36 patients enrolled, the mantle cell lymphoma International Prognostic Index (MIPI) was low in 53%, intermediate in 36% and high in 11%. Thirty-five patients completed at least 2 cycles of chemotherapy; 34 (94%) achieved a CR. After a median follow-up of 74.4 months, the 5-year PFS was 51% (95% CI 33% – 68%) and the 5-year OS was 85% (95% CI 73% – 97%). Two deaths occurred during the chemotherapy phase due to disease progression and neutropenic sepsis respectively. One patient developed secondary acute myeloid leukemia after 7 years. R-MACLO-IVAM chemotherapy is effective for patients with newly diagnosed MCL.
登录
查看更多内容
影响因子：
6.5
作者：
Habermann, Thomas M.;Lossos, Izidore S.;Tuscano, Joseph M.
通讯作者：
Tuscano, Joseph M.
影响因子：
45.3
作者：
Lenz, G;Dreyling, M;Hiddemann, W
通讯作者：
Hiddemann, W
影响因子：
45.3
作者：
Romaguera, JE;Fayad, L;Cabanillas, FF
通讯作者：
Cabanillas, FF
影响因子：
45.3
作者：
Khouri, IF;Romaguera, J;Champlin, R
通讯作者：
Champlin, R
影响因子：
20.3
作者：
Geisler, Christian H.;Kolstad, Arne;Elonen, Erkki
通讯作者：
Elonen, Erkki