Painful cutaneous laser stimuli induce event-related oscillatory EEG activities that are different from those induced by nonpainful electrical stimuli
Painful cutaneous laser stimuli induce event-related oscillatory EEG activities that are different from those induced by nonpainful electrical stimuli
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DOI：
10.1152/jn.00209.2014
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发表时间：
2014-08-15
影响因子：
2.5
通讯作者：
Lenz, F. A.
中科院分区：
文献类型：
--
作者：
Chien, J. H.;Liu, C. C.;Lenz, F. A.
对疼痛刺激的非锁相EEG反应通常被表征为α频带中的振荡活动减少（事件相关去极化，ERD）。最近有报告称，伽马波段的活动（事件相关同步，ERS）增加。我们现在已经测试的假设，即非相位锁定的反应，非痛苦的电皮肤刺激是不同的痛苦的皮肤激光刺激时，这两个刺激的基线显着性是相同的，并在协议期间的显着性调制计数激光和计数电任务。这两种刺激都以随机顺序呈现在一个序列中，其强度在相同的躯体位置产生相同的基线显着性。对激光刺激的反应在时间-频率域中由五个窗口（指定窗口I-V）表征：早期（200-400 ms）和晚期（600- 1，400 ms）δ/θ ERS、500-900 ms α ERD、1，200 - 1，600 ms β ERS（反弹）和800- 1，200 ms γ ERS。电刺激也有类似的ERS/ERD活动窗口。个体参与者通常在与整体分析一致的窗口中进行活动。顶骨通道的ERS/ERD线性回归最常见于感觉（疼痛或不愉快）或注意力（突出性）相关测量。总体而言，模态的主效应在I-δ/θ窗口和V-γ窗口中发现，并且在所有五个窗口中发现了模态与任务的相互作用。所有重要的相互作用项都包括模态作为一个因素。因此，模态是解释我们结果的最常见因素，这与我们的假设一致。
The non-phase-locked EEG response to painful stimuli has usually been characterized as decreased oscillatory activity (event-related desynchronization, ERD) in the alpha band. Increased activity (event-related synchronization, ERS) in the gamma band has been reported more recently. We have now tested the hypothesis that the non-phase-locked responses to nonpainful electric cutaneous stimuli are different from those to painful cutaneous laser stimuli when the baseline salience of the two stimuli is the same and the salience during the protocol is modulated by count laser and count electric tasks. Both of these stimuli were presented in random order in a single train at intensities that produced the same baseline salience in the same somatic location. The response to the laser stimulus was characterized by five windows (designated windows I-V) in the time-frequency domain: early (200-400 ms) and late (600-1,400 ms) delta/theta ERS, 500-900 ms alpha ERD, 1,200-1,600 ms beta ERS (rebound), and 800-1,200 ms gamma ERS. Similar ERS/ERD windows of activity were found for the electric stimulus. Individual participants very commonly had activity in windows consistent with the overall analysis. Linear regression of ERS/ERD for parietal channels was most commonly found for sensory (pain or unpleasantness)- or attention (salience)-related measures. Overall, the main effect for modality was found in window I-delta/theta and window V-gamma, and the Modality with Task interaction was found in all five windows. All significant interaction terms included Modality as a factor. Therefore, Modality was the most common factor explaining our results, which is consistent with our hypothesis.