Detection of reduction in population size using data from microsatellite loci
Detection of reduction in population size using data from microsatellite loci
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DOI：
10.1046/j.1365-294x.2001.01190.x
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发表时间：
2001-02-01
影响因子：
4.9
通讯作者：
Williamson, EG
中科院分区：
文献类型：
--
作者：
Garza, JC;Williamson, EG
我们证明，等位基因的数量的范围内的等位基因大小的平均比率，我们的术语M，计算从一个人口样本的微卫星位点，可以用来检测人口规模的减少。使用模拟，我们表明，对于一般类的突变模型，M的值减少时，人口的大小。减少的幅度与尺寸减少的严重程度和持续时间呈正相关。我们还发现，M的恢复率减少后的大小与减少后的人口规模呈正相关，但恢复发生在小和大的人口。这表明M可以区分最近规模缩小的种群和长期以来规模较小的种群。我们采用M来开发最近人口规模减少的统计测试，可以检测到超过100代的这种变化与减少后的人口情景，我们检查。我们还计算M的各种人群和物种使用微卫星数据收集的文献。我们发现，M的值一致地预测了这些人群的人口统计学历史。这种方法和其他类似的方法有望成为保护和管理需要干预或恢复的种群的重要工具。
We demonstrate that the mean ratio of the number of alleles to the range in allele size, which we term M, calculated from a population sample of microsatellite loci, can be used to detect reductions in population size. Using simulations, we show that, for a general class of mutation models, the value of M decreases when a population is reduced in size. The magnitude of the decrease is positively correlated with the severity and duration of the reduction in size. We also find that the rate of recovery of M following a reduction in size is positively correlated with post-reduction population size, but that recovery occurs in both small and large populations. This indicates that M can distinguish between populations that have been recently reduced in size and those which have been small for a long time. We employ M to develop a statistical test for recent reductions in population size that can detect such changes for more than 100 generations with the post-reduction demographic scenarios we examine. We also compute M for a variety of populations and species using microsatellite data collected from the literature. We find that the value of M consistently predicts the reported demographic history for these populations. This method, and others like it, promises to be an important tool for the conservation and management of populations that are in need of intervention or recovery.