Role of the striatum, cerebellum, and frontal lobes in the learning of a visuomotor sequence
Role of the striatum, cerebellum, and frontal lobes in the learning of a visuomotor sequence
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DOI：
10.1006/brcg.1997.0899
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发表时间：
1997-07-01
影响因子：
2.5
通讯作者：
Bouchard, JP
中科院分区：
文献类型：
--
作者：
Doyon, J;Gaudreau, D;Bouchard, JP
本研究旨在探讨纹状体、小脑和额叶在视觉序列内隐学习中的作用。因此，特发性帕金森病（PD）患者的表现，小脑损伤，或与一个局限性病变的额叶进行了比较，匹配的正常对照组的一个改编版本的重复序列测试。该范式由一个视觉反应时间任务与一个固定的嵌入序列的手指动作，他执行的基础上呈现的视觉刺激。受试者接受了四个试验区组（即，在6个培训日内每天进行40次10项序列的介绍。在最后一次实验之后，受试者还接受了两次测试，测量他们对序列的陈述性知识。只有双侧纹状体功能障碍的PD患者或小脑损伤的患者在最后三次训练中未能改善其表现，因此表明在获得过程的后期存在损伤，进一步的分析显示，这种损伤主要是隐性的，并且不能归因于认知功能的普遍下降，情绪障碍，或运动症状的严重程度。相比之下，三个临床组和他们各自的正常受试者组之间的序列的陈述性知识的水平没有差异。这些发现表明，与陈述性记忆不同，新的视觉技能的增量获得取决于纹状体和小脑的完整性，而不是额叶。(C)北京：科学出版社.
This study was designed to examine the role of the striatum, cerebellum, and frontal lobes; in the implicit learning of a visuomotor sequence. The performance of patients with idiopathic Parkinson's disease (PD), with damage to the cerebellum, or with a circumscribed lesion to the frontal lobes was thus compared to that of separate groups of matched normal control subjects on an adapted version of the Repeated Sequence Test. This paradigm consists of a visual reaction-time task with a fixed embedded sequence of finger movements to he performed based on presentation of visual stimuli. Subjects received four blocks of trials (i.e., 40 presentations of a 10-item sequence) per day over 6 training days. Following the last experimental session, subjects were also given two tests measuring their declarative knowledge of the sequence. Only PD patients with a bilateral striatal-dysfunction or patients with lesions to the cerebellum failed to improve their performance in the last three training sessions, hence suggesting an impairment late in the acquisition process, Further analyses revealed that such impairment was mainly implicit in nature, and that it could not be ascribed to a general decline in cognitive functioning, to mood disturbances, or to the severity of the motor symptoms. By contrast, the level of declarative knowledge of the sequence did not differ between the three clinical groups and their respective groups of normal subjects. These findings suggest that, unlike declarative memory the incremental acquisition of a new visuomotor skill depends upon the integrity of both the striatum and the cerebellum, but not of the frontal lobes. (C) 1997 Academic Press.