Silica Nanotubes Decorated by pH-Responsive Diblock Copolymers for Controlled Drug Release
Silica Nanotubes Decorated by pH-Responsive Diblock Copolymers for Controlled Drug Release
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pH 响应性二嵌段共聚物修饰的二氧化硅纳米管可控制药物释放
DOI：
10.1021/am507832n
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发表时间：
2015
影响因子：
9.5
通讯作者：
Pan Caiyuan
中科院分区：
文献类型：
--
作者：
Zhou Jiemei;Zhang Wenjian;Hong Chunyan;Pan Caiyuan
本文提出了一种新型的纳米容器，它以二氧化硅纳米管（SNT）为核心，在其外表面附着pH敏感聚合物外壳。聚合物纳米棒是通过聚合诱导自组装和重组的方法方便地制备的，它被用作沉积二氧化硅的模板来制备杂化纳米棒。煅烧合成的二氧化硅混合纳米棒导致中空的SNTs。用可逆加成-断裂链转移（RAFT）试剂对碳纳米管进行功能化，然后进行表面RAFT聚合，得到聚（甲基丙烯酸二乙氨基乙酯）-b-聚（低聚乙二醇）甲基丙烯酸酯包覆碳纳米管（SNT-PDEAEMA-b-POEGMA）。多柔比星（DOX）可以包封在SNT-PDEAEMA-b-POEGMA中，并且通过调节介质的pH来实现负载的DOX的受控释放。体外细胞活性和细胞内化研究证实了这种纳米容器在药物和基因递送方面的潜在应用。
A novel nanocontainer, which has silica nanotube (SNT) core and pH-sensitive polymer shell attaching on the exterior surface of silica nanotube, is presented in this paper. Polymer nanorods, which are conveniently fabricated though polymerization-induced self-assembly and reorganization method, are used as templates for the deposition of silica to fabricate hybrid nanorods. Calcination of as-synthesized silica hybrid nanorods leads to hollow SNTs. SNTs are functionalized with reversible addition–fragmentation chain transfer (RAFT) agent, then surface RAFT polymerization is conducted to get poly(2-(diethylamino)ethyl methacrylate)-b-poly(oligo(ethylene glycol) methacrylate)-coated SNTs (SNT-PDEAEMA-b-POEGMA). Doxorubicin (DOX) can be encapsulated in SNT-PDEAEMA-b-POEGMA, and controlled release of loaded DOX is achieved by adjusting pH of the medium. In vitro cell viability and cellular internalization study confirm the potential application of this nanocontainer in drug and gene delivery.