Point: Counterpoint: Respiratory sinus arrhythmia is due to a central mechanism vs. respiratory sinus arrhythmia is due to the baroreflex mechanism
Point: Counterpoint: Respiratory sinus arrhythmia is due to a central mechanism vs. respiratory sinus arrhythmia is due to the baroreflex mechanism
复制标题
DOI：
10.1152/japplphysiol.91107.2008
复制
发表时间：
2009-05-01
影响因子：
3.3
通讯作者：
Eckberg, Dwain L.
中科院分区：
文献类型：
--
作者：
Eckberg, Dwain L.
健康人的血压和心跳周期随呼吸频率波动。一些研究人员（8,23）将其解释为一种因果关系：血压变化触发了血压反射介导的RR间期变化。我认为呼吸性窦性心律失常是一种独立于血压变化的中心现象。我的这一论点基于几个有充分证据的生理事实。迷走-心脏运动神经元膜电位随呼吸频率波动（16），调节迷走运动神经元对动脉压力感受器输入的反应性（12,13），并对迷走-心脏神经交通和心脏周期施加呼吸节律（18）。迷走神经运动神经元反应的中枢呼吸门控（11）足以解释呼吸性窦性心律失常。
Blood pressure and heart periods fluctuate at respiratory frequencies in healthy humans. Some researchers (8, 23) explain this as a cause-and-effect relation: blood pressure changes trigger baroreflex-mediated RR interval changes. Here I make the case that respiratory sinus arrhythmia is a central phenomenon that is independent of blood pressure changes. I base this argument on several well-documented physiological facts.Vagal-cardiac motoneuron membrane potentials fluctuate at respiratory frequencies (16), modulate responsiveness of vagal motoneurons to arterial baroreceptor inputs (12, 13), and impose a respiratory rhythm on vagal-cardiac nerve traffic and heart periods (18). Central respiratory gating of vagal motoneuron responsiveness (11) is sufficient to explain respiratory sinus arrhythmia.