Impact of Body Mass Index on Survival After Colorectal Cancer Diagnosis: The Cancer Prevention Study-II Nutrition Cohort
Impact of Body Mass Index on Survival After Colorectal Cancer Diagnosis: The Cancer Prevention Study-II Nutrition Cohort
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DOI：
10.1200/jco.2011.38.0287
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发表时间：
2012-01-01
影响因子：
45.3
通讯作者：
Gapstur, Susan M.
中科院分区：
文献类型：
--
作者：
Campbell, Peter T.;Newton, Christina C.;Gapstur, Susan M.
研究目的：体重指数（BMI）对结直肠癌诊断后生存率的影响尚不清楚。本研究评估了协会的前和诊断后的BMI与所有原因和原因特异性生存男性和女性诊断为结直肠癌在前瞻性cohol.Patients和MethodsParticipants在癌症预防研究-II营养队列报告的体重和其他危险因素的信息，通过自填问卷在基线在1992年至1993年。通过定期随访问卷报告当前体重和癌症发病率的更新信息。这项分析包括2,303名队列参与者，他们在基线和2007年中期之间被诊断为非转移性结直肠癌，并观察了从诊断到2008年12月的死亡率。结果共有851名结直肠癌参与者在16年的随访期间死亡，其中380人死于结直肠癌，153人死于心血管疾病（CVD）。在对诊断前BMI（1992年至1993年报告的基线体重;平均值，结肠直肠癌诊断前7年）、肥胖BMI（
PurposeThe impact of body mass index (BMI) on survival after colorectal cancer diagnosis is poorly understood. This study assessed the association of pre- and postdiagnosis BMI with all-cause and cause-specific survival among men and women diagnosed with colorectal cancer in a prospective cohort.Patients and MethodsParticipants in the Cancer Prevention Study-II Nutrition Cohort reported weight and other risk factor information via a self-administered questionnaire at baseline in 1992 to 1993. Updated information on current weight and incident cancer was reported via periodic follow-up questionnaires. This analysis includes 2,303 cohort participants who were diagnosed with nonmetastatic colorectal cancer between baseline and mid 2007 and were observed for mortality from diagnosis through December 2008.ResultsA total of 851 participants with colorectal cancer died during the 16-year follow-up period, including 380 as a result of colorectal cancer and 153 as a result of cardiovascular disease (CVD). In analyses of prediagnosis BMI (weight reported at baseline in 1992 to 1993; mean, 7 years before colorectal cancer diagnosis), obese BMI (