Electrooxidative and Regioselective C-H Azolation of Phenol and Aniline Derivatives
Electrooxidative and Regioselective C-H Azolation of Phenol and Aniline Derivatives
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苯酚和苯胺衍生物的电氧化和区域选择性 C-H 偶氮化
DOI：
10.1002/anie.201901762
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发表时间：
2019-06-17
影响因子：
16.6
通讯作者：
Chen, Tianfeng
中科院分区：
文献类型：
--
作者：
Feng, Pengju;Ma, Guojian;Chen, Tianfeng
建立了一种通用、实用的电氧化交叉偶联方法用于苯酚和苯胺衍生物的C-H偶氮化反应。该反应在无金属、无氧化剂和无试剂的条件下进行，从而获得了多种合成有用的杂芳烃衍生物。该反应还可以容忍广泛的官能团，并且可以进行克级合成。最后，初步的机理研究表明，偶联反应可能涉及一条自由基-自由基-结合途径。
A general and practical protocol was developed for the regioselective C-H azolation of phenol and aniline derivatives by electrooxidative cross-coupling. The reaction occurs under metal-, oxidant-, and reagent-free conditions, allowing access to a wide variety of synthetically useful heteroarene derivatives. The reaction also tolerates a broad range of functional groups and is amenable to gram-scale synthesis. Finally, a preliminary mechanistic study indicated that a radical-radical-combination pathway might be involved in the coupling reaction.