DNA mismatch repair system: repercussions in cellular homeostasis and relationship with aging.
DNA mismatch repair system: repercussions in cellular homeostasis and relationship with aging.
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DOI：
10.1155/2012/728430
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发表时间：
2012
影响因子：
--
通讯作者：
Konigsberg M
中科院分区：
文献类型：
--
作者：
Conde-Pérezprina JC;León-Galván MÁ;Konigsberg M
由于 DNA 修复对细胞稳态的影响，近年来人们对其机制进行了研究。影响 DNA 完整性的多种破坏性刺激，例如基因序列的变化和基因表达的修饰，可以破坏细胞的稳态，并对调节细胞凋亡、衰老和癌症的途径产生严重影响。这些改变的途径不仅改变细胞和有机体的寿命，而且改变生活质量（“健康寿命”）。 DNA错配修复系统（MMR）在物种之间高度保守；它在保存 DNA 完整性方面发挥着至关重要的作用，使其成为研究延长寿命、衰老和疾病途径的必要焦点。在这里，我们回顾了有关 DNA-MMR 故障或缺失及其对细胞稳态影响的不同见解。我们将特别关注由已知修复蛋白 MSH2、MSH6、PMS2 和 MHL1 等调节的 DNA-MMR 机制。
The mechanisms that concern DNA repair have been studied in the last years due to their consequences in cellular homeostasis. The diverse and damaging stimuli that affect DNA integrity, such as changes in the genetic sequence and modifications in gene expression, can disrupt the steady state of the cell and have serious repercussions to pathways that regulate apoptosis, senescence, and cancer. These altered pathways not only modify cellular and organism longevity, but quality of life (“health-span”). The DNA mismatch repair system (MMR) is highly conserved between species; its role is paramount in the preservation of DNA integrity, placing it as a necessary focal point in the study of pathways that prolong lifespan, aging, and disease. Here, we review different insights concerning the malfunction or absence of the DNA-MMR and its impact on cellular homeostasis. In particular, we will focus on DNA-MMR mechanisms regulated by known repair proteins MSH2, MSH6, PMS2, and MHL1, among others.
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影响因子：
3.6
作者：
Auerbach, Arleen D.;Verlander, Peter C.
通讯作者：
Verlander, Peter C.
DOI：
10.2307/3504035
发表时间：
1981-01-01
期刊：
Mammalian Species
影响因子：
--
作者：
FITCH J H;SHUMP K A JR;SHUMP A U
通讯作者：
SHUMP A U
影响因子：
4.8
作者：
Geng, Hui;Sakato, Miho;Hsieh, Peggy
通讯作者：
Hsieh, Peggy
影响因子：
4
作者：
Hong, Zehui;Jiang, Jie;Yasui, Akira
通讯作者：
Yasui, Akira
影响因子：
1.4
作者：
Silva, Felipe Cavalcanti Carneiro da;Valentin, Mev Dominguez;Rossi, Benedito Mauro
通讯作者：
Rossi, Benedito Mauro