Neuromodulation of dendritic action potentials
Neuromodulation of dendritic action potentials
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DOI：
10.1152/jn.1999.81.1.408
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发表时间：
1999-01-01
影响因子：
2.5
通讯作者：
Johnston, D
中科院分区：
文献类型：
--
作者：
Hoffman, DA;Johnston, D
再生动作电位侵入海马 CAI 锥体树突的程度取决于最近的活动和与胞体的距离。之前，我们已经证明，通过激活蛋白激酶 A (PKA) 或蛋白激酶 C (PKC) 以及随后树突 K+ 通道激活曲线的去极化偏移，可以增加反向传播树突动作电位的幅度。生理学上，当β-肾上腺素受体和毒蕈碱乙酰胆碱受体激活时，预计细胞内PKA和PKC会分别增加。因此，我们在此报告，这些神经递质系统的激活都会导致树突动作电位幅度的增加。多巴胺能神经递质系统的激活预计也会提高细胞内腺苷 3',5'-环单磷酸 (cAMP) 和 PKA 水平，仅在测试的神经元亚群中增加动作电位幅度。
The extent to which regenerative action potentials invade hippocampal CAI pyramidal dendrites is dependent on both recent activity and distance from the soma. Previously, we have shown that the amplitude of back-propagating dendritic action potentials can be increased by activating either protein kinase A (PKA) or protein kinase C (PKC)and a subsequent depolarizing shift in the activation curve for dendritic K+ channels. Physiologically, an increase in intracellular PKA and PKC would be expected upon activation of beta-adrenergic and muscarinic acetylcholine receptors, respectively. Accordingly, we report here that activation of either of these neurotransmitter systems results in an increase in dendritic action-potential amplitude. Activation of the dopaminergic neurotransmitter system, which is also expected to raise intracellular adenosine 3',5'-cyclic monophosphate (cAMP) and PKA levels, increased action-potential amplitude in only a subpopulation of neurons tested.