Antigen-specific lymphocyte sequestration in lymphoid organs:: Lack of essential roles for αL and α4 integrin-dependent adhesion or Gαi protein-coupled receptor signaling
Antigen-specific lymphocyte sequestration in lymphoid organs:: Lack of essential roles for αL and α4 integrin-dependent adhesion or Gαi protein-coupled receptor signaling
复制标题
DOI：
10.4049/jimmunol.173.2.866
复制
发表时间：
2004-07-15
影响因子：
4.4
通讯作者：
Campbell, DJ
中科院分区：
文献类型：
--
作者：
Arnold, CN;Butcher, EC;Campbell, DJ
选择性淋巴细胞隔离在30多年前被描述为Ag特异性淋巴细胞由于在次级淋巴器官中活化而从循环中短暂撤回。我们使用了TCR转基因过继转移系统，以进一步表征小鼠中该过程的Ag和佐剂依赖性。此外，我们研究了α（L）和α（4）整联蛋白链以及G α（i）蛋白偶联受体信号传导对外周淋巴结中Ag特异性T细胞保留的贡献。我们的研究结果表明，选择性淋巴细胞隔离是T细胞自主和佐剂的独立性，隔离的持续时间是不控制的持续存在的Ag在次级淋巴器官。该过程并不严重依赖于α（L）和α（4）整联蛋白链或α（i）蛋白偶联受体信号传导。选择性淋巴细胞隔离可以通过冗余机制介导和/或由新的或非经典的粘附或运输分子控制。
Selective lymphocyte sequestration was described over 30 years ago as the transient withdrawal of Ag-specific lymphocytes from the circulation as a result of their activation in secondary lymphoid organs. We used a TCR-transgenic adoptive transfer system to further characterize the Ag and adjuvant dependence of this process in mice. In addition, we examined the contribution of the alpha(L) and alpha(4) integrin chains as well as Galpha(i) protein-coupled receptor signaling to the retention of Ag-specific T cells in peripheral lymph nodes. Our results demonstrate that selective lymphocyte sequestration is T cell autonomous and adjuvant independent, and that the duration of sequestration is not controlled by the continued presence of Ag in secondary lymphoid organs. This process is not critically dependent on the alpha(L) and alpha(4) integrin chains or Galpha(i) protein-coupled receptor signaling. Selective lymphocyte sequestration may be mediated by redundant mechanisms and/or controlled by novel or nonclassical adhesion or trafficking molecules.