Suppression of HHV-8 viremia by foscarnet in an HIV-infected patient with Kaposi's sarcoma and HHV-8 associated hemophagocytic syndrome.
Suppression of HHV-8 viremia by foscarnet in an HIV-infected patient with Kaposi's sarcoma and HHV-8 associated hemophagocytic syndrome.
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膦甲酸对患有卡波西肉瘤和 HHV-8 相关噬血细胞综合征的 HIV 感染患者抑制 HHV-8 病毒血症。
DOI：
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发表时间：
1998
影响因子：
4.2
通讯作者：
T. Harrer
中科院分区：
文献类型：
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作者：
P. Löw;F. Neipel;A. Rascu;H. Steininger;B. Manger;B. Fleckenstein;J. Kalden;T. Harrer
人疱疹病毒8型（HHV-8）似乎参与卡波西肉瘤的发病机制。在体外，抗疱疹病毒的抗病毒药物也能抑制HHV-8，然而，对HHV-8的体内抗病毒活性知之甚少。在这份报告中，我们描述了膦甲酸对HHV-8病毒血症的影响，在一个HIV感染的病人与播散性卡波西肉瘤和一个可能的HHV-8相关的噬血细胞综合征。PCR法检测外周血单个核细胞（PBMC）、支气管肺泡液和肿瘤组织中HHV-8 DNA。由于严重的噬血细胞综合征，开始使用膦甲酸后，PBMC中HHV-8 PCR转为阴性，但胸腔积液和肿瘤活检中保持阳性。膦甲酸治疗结束后，PBMC中HHV-8 DNA持续出现。在膦甲酸治疗下，噬血细胞综合征显著改善，表明HHV-8在该综合征中具有致病作用。
Human herpes virus 8 (HHV-8) seems to be involved in the pathogenesis of Kaposi s sarcoma. In vitro, antiviral drugs with activity against herpes viruses also can suppress HHV-8, however, little is known about the antiviral activity against HHV-8 in vivo. In this report we describe the effects of foscarnet on HHV-8 viremia in an HIV-infected patient with disseminated Kaposi s sarcoma and a presumably HHV-8 associated hemophagocytic syndrome. HHV-8 DNA could be detected in this patient by PCR in peripheral blood mononuclear cells (PBMC), in bronchoalveolar fluid and tumor biopsies. After initiation of foscarnet because of a severe hemophagocytic syndrome HHV-8 PCR turned negative in PBMC, but stayed positive in pleural effusions and in a tumor biopsy. After termination of foscarnet therapy HHV-8 DNA in PBMC persistently reappeared. Under treatment with foscarnet the hemophagocytic syndrome dramatically improved, suggesting that HHV-8 had a pathogenetic role in this syndrome.