Angiographic Risk Features of Branch Retinal Vein Occlusion Onset as Determined by Optical Coherence Tomography Angiography
Angiographic Risk Features of Branch Retinal Vein Occlusion Onset as Determined by Optical Coherence Tomography Angiography
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DOI：
10.1167/iovs.61.2.8
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发表时间：
2020-02-01
影响因子：
4.4
通讯作者：
Tsujikawa, Akitaka
中科院分区：
文献类型：
--
作者：
Kogo, Takahiro;Muraoka, Yuki;Tsujikawa, Akitaka
目的.研究动静脉交叉处血管与视网膜分支静脉阻塞（BRVO）发病之间的关系。我们纳入了78例严重BRVO患者、35例黄斑BRVO患者和110例无BRVO的对照组，并在光学相干断层扫描血管造影（OCTA）中使用12 x 12 mm（2）的视角确定AV交叉处的血管位置，其中视网膜静脉的一级或二级分支相关。我们分别回顾了BRVO患者和对照组的1349例和1276例AV交叉。在BRVO眼、非BRVO对侧眼和未受影响的对照眼中，非病因交叉处静脉交叉的比例分别为26.5%、28.6%和26.8%;然而，病因交叉处静脉交叉的比例为45.1%。在OCTA分析中，我们将分支分为黄斑静脉或非黄斑静脉。主要BRVO的静脉交叉率为52.5%，而黄斑BRVO的静脉交叉率为28.6%。静脉交叉是否是BRVO风险因素的比值比在非黄斑静脉和黄斑静脉中分别为3.09（95%置信区间[CIL 1.96-4.88]）和0.94（95% CI，0.44-2.00）。静脉交叉引起的严重BRVO患者比动脉交叉引起的患者年轻（P < 0.001）。黄斑BRVO的发生在不同的交叉模式之间没有差异（P = 0.60）。在患有BRVO的眼睛中，静脉交叉是一种常见的血管造影特征，可能是主要BRVO发作的危险因素。
PURPOSE. Examine associations between the vasculature at arteriovenous (AV) crossings and the onset of branch retinal vein occlusion (BRVO).METHODS. We included 78 patients with major BRVO, 35 patients with macular BRVO, and 110 controls without BRVO and determined the vessel positions at AV crossings, where the first- or second-order branches of the retinal veins associate, using a viewing angle of 12 x 12 mm(2) in optical coherence tomography angiography (OCTA).RESULTS. We reviewed 1349 and 1276 AV crossings in BRVO patients and control subjects, respectively. The proportions of venous overcrossing were 26.5%, 28.6%, and 26.8% at non-causative crossings in BRVO eyes, non-BRVO fellow eyes, and unaffected control eyes, respectively; however, the rate of venous overcrossings at the causative crossings was 45.1%. In OCTA analyses, we divided the branches into macular- or non-macular veins. The rate of venous overcrossing was 52.5% at causative crossings in major BRVO but was 28.6% in macular BRVO. Odds ratios for whether venous overcrossing was a risk factor for BRVO were 3.09 (95% confidence interval [CIL 1.96-4.88) and 0.94 (95% CI, 0.44-2.00) for non-macular veins and macular veins, respectively. The patients with major BRVO caused by venous overcrossing were younger than patients for whom the cause was arterial overcrossing (P < 0.001). The onset of macular BRVO did not differ between crossing patterns at causative crossings (P = 0.60).CONCLUSIONS. In eyes with BRVO, venous overcrossing was a common angiographic feature at causative crossings and might be a risk factor for major BRVO onset.