2 NEW MUTANTS, TREMBLER AND REELER, WITH NEUROLOGICAL ACTIONS IN THE HOUSE MOUSE (MUS-MUSCULUS L)
2 NEW MUTANTS, TREMBLER AND REELER, WITH NEUROLOGICAL ACTIONS IN THE HOUSE MOUSE (MUS-MUSCULUS L)
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DOI：
10.1007/bf02996215
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发表时间：
1951-01-01
影响因子：
1.5
通讯作者：
FALCONER, DS
中科院分区：
文献类型：
--
作者：
FALCONER, DS
本文描述了家鼠的两个新的突变体，Trembler （Tr）和Reeler （rl）。震颤是由自发的性腺体突变引起的，导致了花叶性性腺。它会导致痉挛性麻痹，在后腿中更为严重，在成年动物中，当动物休息时，全身震颤会停止。年轻人受到刺激时会抽搐。生存能力可能有所降低，这可能是Tr/+雌性后代缺乏Tremblers的原因。外显是完全的。雌性正常繁殖，但雄性经常不育。与性别、a、b、c、p、d、s、wa-1、bt、Ca的连锁检验均为阴性。Reeler是一种隐性基因，由自发突变产生。患此病的动物不能保持后腿直立，走路或跑步时经常侧身摔倒。生存能力有所降低，但很少有动物在分类之前死亡。一只雌性繁殖，但不抚养幼崽；所有测试过的雄性都是不育的。外显完全，分离正常。与性别、a、b、c、d和bt的连锁试验均为阴性。
This paper describes two new mutants in the house mouse, Trembler (Tr) and Reeler (rl). Trembler arose by spontaneous gonosomic mutation resulting in a mosaic gonad. It produces a spastic paralysis, more severe in the hind legs, and in the adult a generalized tremor that ceases when the animal is at rest. The young exhibit convulsions when stimulated. Viability is probably somewhat reduced, and this may have been the cause of a deficiency of Tremblers in the progeny of Tr/+females. Penetrance is complete. Females breed normally but males are frequently sterile. Linkage tests with sex, a,b,c,p, d, s, wa-1, bt and Ca were all negative. Reeler, a recessive gene, arose by spontaneous mutation. Affected animals are unable to keep their hindquarters upright, and when walking or running they frequently fall over on their sides. Viability is somewhat reduced, but few animals die before classification can be made. One female bred but did not rear her young; all the males that have been tested have been sterile. Penetrance is complete and the segregation is normal. Linkage tests with sex, a, b, c, d and bt were all negative.