Inter-individual stereotypy of the Platynereis larval visual connectome.
Inter-individual stereotypy of the Platynereis larval visual connectome.
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DOI：
10.7554/elife.08069
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发表时间：
2015-06-10
期刊：
影响因子：
7.7
通讯作者：
Jékely G
中科院分区：
文献类型：
--
作者：
Randel N;Shahidi R;Verasztó C;Bezares-Calderón LA;Schmidt S;Jékely G
发育程序能够保真地在同一物种的个体之间形成具有相同结构和功能的神经回路。然而，人们不太清楚不同个体的整个神经回路在多大程度上相似。此前，我们报道了扁沙蚕幼虫头部视眼回路的神经元连接组。我们现在报告了另一个同龄幼虫的全身连续切片透射电子显微镜（ssTEM）数据集，我们描述了视觉眼睛和幼虫眼点的连接组。两个回路的解剖比较和定量分析揭示了细胞补体、神经元投射和突触连接的高度个体间刻板印象，包括一些神经元连接的左右不对称。我们的工作展示了扁翅幼虫的眼睛电路的硬连线程度。 DOI：http://dx.doi.org/10.7554/eLife.08069.001
Developmental programs have the fidelity to form neural circuits with the same structure and function among individuals of the same species. It is less well understood, however, to what extent entire neural circuits of different individuals are similar. Previously, we reported the neuronal connectome of the visual eye circuit from the head of a Platynereis dumerilii larva. We now report a full-body serial section transmission electron microscopy (ssTEM) dataset of another larva of the same age, for which we describe the connectome of the visual eyes and the larval eyespots. Anatomical comparisons and quantitative analyses of the two circuits reveal a high inter-individual stereotypy of the cell complement, neuronal projections, and synaptic connectivity, including the left-right asymmetry in the connectivity of some neurons. Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired. DOI: http://dx.doi.org/10.7554/eLife.08069.001