fMRI evidence that precision ophthalmic tints reduce cortical hyperactivation in migraine.
fMRI evidence that precision ophthalmic tints reduce cortical hyperactivation in migraine.
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DOI：
10.1177/0333102411409076
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Cao Y
中科院分区：
文献类型：
--
作者：
Huang J;Zong X;Wilkins A;Jenkins B;Bozoki A;Cao Y
某些模式可导致大多数人的知觉错觉/扭曲和视觉不适，偏头痛患者的头痛，以及光敏性癫痫患者的癫痫发作。视觉刺激是偏头痛发作的常见诱因，可能是因为偏头痛患者的视觉皮质表现出过度兴奋。精准的眼部色调(POTS)声称可以减少一些患者的知觉扭曲和视觉不适，并防止偏头痛。我们报道了一项旨在研究POTS对偏头痛有益作用的神经学机制的fMRI视觉皮质激活研究。11名偏头痛患者和11名年龄和性别匹配的非头痛对照组参与了这项研究，他们使用灰色、花盆和对照有色镜片观察的无压力和有压力的条纹图案。对于所有的镜片，对照组和偏头痛患者对无压力模式的反应没有不同。当偏头痛患者佩戴灰色镜片或对照有色镜片时，压力模式会导致比对照组更强的激活。纹状体外视觉区域也缺乏典型的低通空间频率(SF)调谐。然而，当佩戴POTS时，皮质激活和SF调谐都正常化了。无论是在观察紧张的模式时，还是在更典型的观看条件下，POTS都比其他两种镜片中的任何一种都更能减少视觉不适。POTS对偏头痛患者皮质激活和SF调谐的正常化表明，这些镜片在减少偏头痛患者视觉皮质过度激活方面的疗效具有神经学基础。
Certain patterns can induce perceptual illusions/distortions and visual discomfort in most people, headaches in patients with migraine, and seizures in patients with photosensitive epilepsy. Visual stimuli are common triggers for migraine attacks, possibly because of a hyperexcitability of the visual cortex shown in patients with migraine. Precision ophthalmic tints (POTs) are claimed to reduce perceptual distortions and visual discomfort and to prevent migraine headaches in some patients. We report an fMRI visual cortical activation study designed to investigate neurological mechanisms for the beneficial effects of POTs in migraine. Eleven migraineurs and 11 age- and sex-matched non-headache controls participated in the study using non-stressful and stressful striped patterns viewed through gray, POT, and control coloured lenses. For all lenses, controls and migraineurs did not differ in their response to the non-stressful patterns. When the migraineurs wore gray lenses or control coloured lenses, the stressful pattern resulted in activation that was greater than in the controls. There was also an absence of the characteristic low-pass spatial frequency (SF) tuning in extrastriate visual areas. When POTs were worn, however, both cortical activation and SF tuning were normalized. Both when observing the stressful pattern and under more typical viewing conditions, the POTs reduced visual discomfort more than either of the other two lenses. The normalization of cortical activation and SF tuning in the migraineurs by POTs suggests a neurological basis for the therapeutic effect of these lenses in reducing visual cortical hyperactivation in migraine.
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影响因子：
5.5
作者：
CAMPBELL, FW;ROBSON, JG
通讯作者：
ROBSON, JG
影响因子：
2.5
作者：
LEVITT, JB;KIPER, DC;MOVSHON, JA
通讯作者：
MOVSHON, JA
影响因子：
5
作者：
Aurora, SK;Cao, Y;Welch, KMA
通讯作者：
Welch, KMA
影响因子：
5.7
作者：
Singh, KD;Smith, AT;Greenlee, MW
通讯作者：
Greenlee, MW
DOI：
10.1016/0013-4694(55)90005-5
发表时间：
1955-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
VANHARREVELD, A;STAMM, JS
通讯作者：
STAMM, JS