Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb
Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb
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Houttuynia cordata Thunb 中的黄酮类鱼腥草素 A 的抗单纯疱疹病毒 1 型活性
DOI：
10.1016/j.antiviral.2017.06.010
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发表时间：
2017-08-01
影响因子：
7.6
通讯作者：
Peng, Tao
中科院分区：
文献类型：
--
作者：
Li, Ting;Liu, Libao;Peng, Tao
单纯疱疹病毒1型（HSV-1）感染的早期事件在无环鸟苷（ACV）的存在下重新激活潜伏的人免疫缺陷病毒、爱泼斯坦巴尔病毒和人乳头瘤病毒。核苷类似物药物如无环鸟苷（ACV）和帕多瓦韦（pavirvir）的普遍使用导致临床治疗中出现了耐药HSV-1菌株。因此，应开发能够抑制HSV-1感染早期事件的新的抗疱疹药物。这种治疗的一个例子是鱼腥草。水提取物，其可以通过多种机制抑制HSV-1感染。本研究对一种新的黄酮类化合物HavenoidA的抗HSV-1活性进行了研究。cordata，进行了调查。三种不同的试验证实，该化合物可以表现出较强的体外抗HSV-1活性。一项试验证实，该化合物可抑制HSV-1增殖并防止HSV-1感染小鼠模型中的病变形成。机理分析表明，该化合物通过阻断病毒膜融合而抑制HSV-1的感染性。此外，类肝素A表现出抗其他α疱疹病毒，如HSV-2和水痘带状疱疹病毒（VZV）的抗病毒活性。结论：类肝素A可能是一种有效的抗HSV-1病毒药物。(C)2017爱思唯尔B. V.保留所有权利。
Early events in herpes simplex virus type 1 (HSV-1) infection reactivate latent human immunodeficiency virus, Epstein Barr virus, and human papillomavirus in the presence of acyclovir (ACV). The common use of nucleoside analog medications, such as ACV and pencyclovir, has resulted in the emergence of drug resistant HSV-1 strains in clinical therapy. Therefore, new antiherpetics that can inhibit early events in HSV-1 infection should be developed. An example of this treatment is Houttuynia cordata Thunb. water extract, which can inhibit HSV-1 infection through multiple mechanisms. In this study, the anti-HSV-1 activity of Houttuynoid A, a new type of flavonoid isolated from H. cordata, was investigated. Three different assays confirmed that this compound could exhibit strong in vitro anti-HSV-1 activity. One assay verified that this compound could inhibit HSV-1 multiplication and prevent lesion formation in a HSV-1 infection mouse model. Mechanism analysis revealed that this compound could inactivate HSV-1 infectivity by blocking viral membrane fusion. Moreover, Houttuynoid A exhibited antiviral activities against other alpha herpes viruses, such as HSV-2 and varicella zoster virus (VZV). In conclusion, Houttuynoid A may be a useful antiviral agent for HSV-1. (C) 2017 Elsevier B.V. All rights reserved.