Palladium-catalyzed fluorination of carbon-hydrogen bonds
Palladium-catalyzed fluorination of carbon-hydrogen bonds
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DOI：
10.1021/ja061943k
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发表时间：
2006-06-07
影响因子：
15
通讯作者：
Sanford, Melanie S.
中科院分区：
文献类型：
--
作者：
Hull, Kami L.;Anani, Waseem Q.;Sanford, Melanie S.
该通信描述了一种新的Pd催化方法的发展，用于碳-氢键的重链。这些转变的关键步骤涉及钯介导的碳氟耦合，这是一种备受追捧但前所未有的转变。这些反应成功地实现了氧化条件下使用electrophilicN-氟吡啶试剂。微波辐射在催化乙酸钯的存在下作为最佳条件的取代的2-芳基吡啶和8-甲基喹啉衍生物的C-H键的取代。
This communication describes the development of a new Pd-catalyzed method for the fluorination of carbon−hydrogen bonds. A key step of these transformations involves palladium-mediated carbon−fluorine couplinga much sought after, but previously unprecedented, transformation. These reactions were successfully achieved under oxidative conditions using electrophilicN-fluoropyridinium reagents. Microwave irradiation in the presence of catalytic palladium acetate served as optimal conditions for the fluorination of C−H bonds in a variety of substituted 2-arylpyridine and 8-methylquinoline derivatives.