Acorbine, a Corbicula japonica-derived tripeptide containing non-proteinogenic amino acids, suppresses ethanol-induced liver injury.
Acorbine, a Corbicula japonica-derived tripeptide containing non-proteinogenic amino acids, suppresses ethanol-induced liver injury.
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Acorbine 是一种源自蚬壳的三肽，含有非蛋白氨基酸，可抑制乙醇引起的肝损伤。
DOI：
10.1016/j.bbrc.2019.11.131
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Tagawa Y
中科院分区：
文献类型：
--
作者：
Tamai M;Uchisawa H;Saito Y;Matsue H;Kawase M;Naraoka T;Tagawa Y
自古以来，日本人就认为corbicula提取物具有保护肝脏的作用，但目前尚不清楚这些说法是否属实，如果属实，那么是哪种成分起到了保护肝脏的作用。在本研究中，我们发现corbicula提取物对肝损伤具有保护作用。最近的研究在corbicula japonica的提取物中发现了一种含有非蛋白氨基酸的新型三肽acorbine （β-alanyl-ornithyl-ornithine）。合成阿克拜碱治疗小鼠酒精性肝损伤。此外，从corbicula提取物中纯化的acorbine在小鼠ES/iPS细胞培养肝模型中对酒精诱导的肝毒性具有保护作用。因此，牛膝碱是牛膝提取物中保护肝细胞免受乙醇诱导死亡的成分之一。
Since ancient times,Corbiculaextract has been believed in Japan to have hepatoprotective effects, but it remains unclear whether these claims are true, and if so, which component is responsible for hepatoprotection. In this study, we showed thatCorbiculaextract exerted a protective effect against liver damage. Recent work identified acorbine (β-alanyl-ornithyl-ornithine), a novel tripeptide containing non-proteinogenic amino acids, in the extract ofCorbicula japonica. Synthesized acorbine cured alcohol-induced liver damage in mice. In addition, acorbine purified fromCorbiculaextract exerted a protective effect against alcohol-induced hepatotoxicity in a culture liver model derived from mouse ES/iPS cells. Thus, acorbine is one of the components ofCorbiculaextract that protects hepatocytes against ethanol-induced death.