Neuromuscular blockade in adult intensive care.
Neuromuscular blockade in adult intensive care.
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成人重症监护中的神经肌肉阻滞。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
Topulos Gp
中科院分区：
文献类型：
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作者：
Topulos Gp
神经肌肉阻滞剂是强效药物，在重症监护医学中使用频率越来越高。特定肌肉松弛剂的选择受患者的基础状况和药物副作用的影响。许多因素会影响个体对神经肌肉阻滞剂的反应，因此，应使用神经刺激器监测每个患者的反应。当使用肌肉松弛剂时，常见的并发症是继发于镇痛和镇静不足的患者意识，以及神经肌肉阻滞剂过量。神经肌肉阻滞剂停药后持续数天至数周的瘫痪是一种罕见但破坏性的并发症，其病因尚不清楚。重症监护医学的医生应该接受神经肌肉阻滞药物使用的正式培训。
Neuromuscular blocking agents are powerful drugs that are being used with increasing frequency in critical care medicine. The choice of a particular muscle relaxant is influenced by the patient's underlying condition and the side-effects of the drugs. Many factors influence an individual's response to neuromuscular blocking agents, and therefore, each patient's response should be monitored with a nerve stimulator. When muscle relaxants are used, common complications are patient awareness secondary to inadequate analgesia and sedation, and overdose of the neuromuscular blocking agents. Prolonged paralysis for days to weeks after the discontinuation of neuromuscular blocking agents is an uncommon but devastating complication, the etiology of which is poorly understood. Physicians in critical care medicine should receive formal training in the use of neuromuscular blocking drugs.