ALKALOIDS OF PHYSOSTIGMA VENENOSUM .10. SYNTHESIS AND ANTI-ACETYLCHOLINESTERASE ACTIVITIES OF (+)-PHYSOSTIGMINE AND (+)-PHYSOVENINE
ALKALOIDS OF PHYSOSTIGMA VENENOSUM .10. SYNTHESIS AND ANTI-ACETYLCHOLINESTERASE ACTIVITIES OF (+)-PHYSOSTIGMINE AND (+)-PHYSOVENINE
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DOI：
10.1111/j.2042-7158.1970.tb08469.x
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发表时间：
1970-01-01
影响因子：
3.3
通讯作者：
ROBINSON, B
中科院分区：
文献类型：
--
作者：
DALE, FJ;ROBINSON, B
合成了(+)-蛇黄碱和(+)-蛇黄碱。在玻璃体红细胞乙酰胆碱酯酶研究中发现，这两种碱基的抗乙酰胆碱酯酶活性远低于相应的生物碱(-)-蛇毒碱和(-)-蛇毒碱的活性。讨论了这些活动差异的可能原因。
(+)-Physostigmine and (+)-physovenine have been synthesized. The anti-acetylcholinesterase activities of these two bases, which have been investigatedin vitrousing erythrocyte acetylcholinesterase, have been found to be much lower than the corresponding activities of the alkaloids (-)-physostigmine and (-)-physovenine. Possible reasons for these activity differences are discussed.