PEG-b-polyamine Stabilized Bionanoparticles for Nanodiagnostics and Nanotherapy
PEG-b-polyamine Stabilized Bionanoparticles for Nanodiagnostics and Nanotherapy
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DOI：
10.1246/cl.2008.564
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发表时间：
2008-05
影响因子：
1.6
通讯作者：
Y. Nagasaki
中科院分区：
文献类型：
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作者：
Y. Nagasaki
采用两种不同的聚合工艺合成了聚乙二醇聚(N，N-二甲氨基)甲基丙烯酸乙酯嵌段共聚物(R-PEGb-PAMA)。利用R-聚乙二醇b-PAMA嵌段共聚物，制备了金纳米粒子。所制得的聚乙二醇b-聚甲基丙烯酸甲酯不仅作为金酸根离子的还原剂，而且在得到的纳米粒子表面也起到了配位作用。得到的GNP具有可控的大小和窄的粒度分布。由于表面有聚乙二醇系链链，因此具有极高的分散稳定性。同样的策略也适用于其他纳米粒子，如半导体量子点和无机多孔纳米粒子。利用所制备的聚乙二醇化的GNPs，在分子识别、siRNA释放和酶固定化等方面进行了应用。本文对这些材料的功能进行了介绍。
Poly(ethylene glycol)-b-poly(2-(N,N-dimethylamino)ethyl methacrylate) block copolymers possessing a reactive group at the PEG chain end (R-PEG-b-PAMA) was synthesized by two different polymerization techniques. Using R-PEG-b-PAMA block copolymer thus obtained, gold nanoparticles (GNPs) were prepared. The PEG-b-PAMA worked as not only reducing agent of aurate ions but also coordination on the obtained nanoparticle surface. The obtained GNP had controlled sizes and narrow size distributions. It is also showed extremely high dispersion stability due to the PEG tethering chains on the surface. The same strategy could be applicable to other nanoparticles such as semiconductor quantum dot and inorganic porous nanoparticles. Using PEGylated GNPs thus prepared, several applications such as molecular recognitions, siRNA release and enzyme immobilizations were carried out. The functionalities of these materials are described in this review.