Neurotrophin Receptors: Old Friends with New Partners
Neurotrophin Receptors: Old Friends with New Partners
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DOI：
10.1002/dneu.20767
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发表时间：
2010-04-01
影响因子：
3
通讯作者：
Bothwell, Mark
中科院分区：
文献类型：
--
作者：
Schecterson, Leslayann C.;Bothwell, Mark
神经营养因子是脊椎动物神经系统中大多数神经元的胚胎发育和成体功能的重要调节因子。这个信号系统调节许多不同的活动，包括存活、轴突生长和突触可塑性。在哺乳动物中，神经营养因子的作用由四种受体介导，即p75（NTR）、TrkA、TrkB和TrkC。虽然早期的研究将这些受体视为细胞外膜中的孤立因子，但最近的发现表明，细胞外膜是一个拥挤且高度相互作用的社区。神经营养因子受体与多种膜蛋白合作，极大地扩展了它们的功能库。本文将重点介绍神经营养因子受体混杂配对的最新发现。(C) 2010 Wiley期刊公司中国生物医学工程杂志（英文版），2010
Neurotrophins are important regulators of embryonic development and adult function of most populations of neurons in vertebrate nervous systems. This signaling system regulates many diverse activities, including survival, axon outgrowth, and synaptic plasticity. In mammals, neurotrophin action is mediated by four receptors, p75(NTR), TrkA, TrkB, and TrkC. Although early studies viewed these receptors as solitary agents in the cells outer membrane, recent discoveries reveal that the cell outer membrane is a crowded and highly interactive neighborhood. Neurotrophin receptors partner with a diverse array of membrane proteins, dramatically expanding their functional repertoire. This review will focus on some of the most recent discoveries concerning the promiscuous partnering of neurotrophin receptors. (C) 2010 Wiley Periodicals, Inc. Develop Neurobiol 70: 332-338, 2010