Translational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations.
Translational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations.
复制标题
艰难梭菌感染免疫学的转化方面：对儿童群体的影响。
DOI：
10.1093/jpids/piab089
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发表时间：
2021
影响因子：
3.2
通讯作者：
Savidge,Tor
中科院分区：
文献类型：
--
作者：
Kociolek,LarryK;Zackular,JosephP;Savidge,Tor
艰难梭状芽胞杆菌已成为美国最常见的医疗保健相关病原体，美国疾病控制与预防中心（CDC）将其列为c类。艰难梭菌是一种“紧急”的公共卫生威胁，需要“紧急和积极的行动”。这一行动呼吁带来了新的发现，提高了我们对艰难梭菌感染（CDI）免疫学的理解和CDI预防免疫治疗的临床发展。然而，CDI免疫学研究在儿科人群中受到限制，并且关于宿主免疫反应在儿童CDI发病机制中的功能以及免疫治疗在儿童中的潜在作用仍存在一些未解之谜。本文综述了先前在动物和人类中表现出的先天免疫和适应性免疫反应，并提供了成人和儿童CDI预防免疫治疗的最新临床进展。这些数据为未来对儿童的研究需求提供了信息。
Clostridioides difficilehas become the most common healthcare-associated pathogen in the United States, leading the US Centers for Disease Control and Prevention (CDC) to classifyC. difficileas an “urgent” public health threat that requires “urgent and aggressive action.” This call to action has led to new discoveries that have advanced our understanding ofClostridioides difficileinfection (CDI) immunology and clinical development of immunologic-based therapies for CDI prevention. However, CDI immunology research has been limited in pediatric populations, and several unanswered questions remain regarding the function of host immune response in pediatric CDI pathogenesis and the potential role of immunologic-based therapies in children. This review summarizes the innate and adaptive immune responses previously characterized in animals and humans and provides a current update on clinical development of immunologic-based therapies for CDI prevention in adults and children. These data inform the future research needs for children.