Predoctoral and Postdoctoral Training Pipeline in Translational Biomaterials Research and Regenerative Medicine.
Predoctoral and Postdoctoral Training Pipeline in Translational Biomaterials Research and Regenerative Medicine.
复制标题
转化生物材料研究和再生医学的博士前和博士后培训管道。
DOI：
10.1021/acsbiomaterials.7b00268
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发表时间：
2018
影响因子：
5.8
通讯作者：
Kohn,Joachim
中科院分区：
文献类型：
--
作者：
Grinstaff,MarkW;Kaplan,HiltonM;Kohn,Joachim
将基于生物材料的再生疗法从实验室转化为患者涉及多种挑战。最紧迫的挑战之一是教育方面的挑战：培养一批能够将他们的发现从实验室转化为市场再到临床的科学家和工程师。为了满足这一需求，翻译培训计划正在全球范围内的大学以及大学和公司之间的合作伙伴关系中实施。从这个角度来看，我们描述了两个翻译NIH T32研究生和研究生培训计划，增加了传统的方法来培养早期的科学家和工程师。在研究生阶段，波士顿大学开发并实施了生物材料转化研究（TRB）博士前培训计划。在研究生阶段，罗格斯大学，新泽西的州立大学，开发和实施了再生医学转化研究（TRRM）博士后培训计划。这些计划的动机是需要在生物医学领域的转化研究的培训，由年轻科学家的要求，这种培训，并面临未来的发现和基于生物材料的技术的临床实施的根本挑战。TRB计划让学员沉浸在将研究实验室的想法转化为临床的概念中，向他们介绍这种奋进的挑战，与相关教师进行讨论（例如，与企业，患者护理或临床试验经验），并在他们未来职业所需的关键领域教育他们。同样，TRRM计划强调转化研究和“无国界培训”的概念，这使得几个地理上分散的机构之间的合作成为可能，从而使区域专家无论身在何处都可以访问。这两个项目都促进跨学科研究，让年轻的科学家和工程师接触到他们专业之外的挑战，并培养跨学科沟通的人际交往能力。TRB计划侧重于定量科学和工程课程，以及临床试验和商业的预防性课程。TRRM计划的重点是通过接触比传统博士后计划更广泛的导师网络来拓宽学员的视野，并鼓励学员参与至少两个不同实验室的合作研究。这两个项目都满足了重要的公共卫生需求：学员获得的技能在未来的生物医学职业生涯中至关重要，因为他们加入了联合收割机不同背景的团队，以实现研究，开发和最终商业化的共同目标。
The translation of biomaterial based and regenerative therapies from the laboratory to patients involves multiple challenges. One of the most pressing challenges is the educational one: to train a cohort of scientists and engineers capable of translating their discoveries from bench to market to clinic. To meet this need, translational training programs are being implemented globally at universities and as partnerships between universities and corporations. In this perspective, we describe two translational NIH T32 graduate and postgraduate training programs that augment the traditional approach to training early stage scientists and engineers. At the graduate level, Boston University developed and implemented the Translational Research in Biomaterials (TRB) predoctoral training program. At the postgraduate level, Rutgers, The State University of New Jersey, developed and implemented the Translational Research in Regenerative Medicine (TRRM) program for postdoctoral training. These programs are motivated by the need for training in translational research in the biomedical field, by young scientists’ requests for such training, and by the fundamental challenges facing future discovery and clinical implementation of biomaterial-based technologies. The TRB program immerses trainees in the concept of translating an idea from the research laboratory to the clinic, introduces them to the challenges of such an endeavor, provides discussions with relevant faculty (for example, with businesses, patient care, or clinical trial experience), and educates them in the critical areas required for their future careers. Similarly, the TRRM program emphasizes translational research and the concept of “training without borders,” which enables collaborations across several geographically dispersed institutions so as to make regional experts accessible regardless of where they are located physically. Both programs promote interdisciplinary research, expose young scientists and engineers to challenges outside of their specialty, and build interpersonal skills for cross-disciplinary communication. The TRB program focuses on quantitative science and engineering courses, together with translation-based courses in clinical trials and business. The TRRM program focuses on broadening the horizon of its trainees through exposure to a wider network of mentors than traditional postdoctoral programs, and by encouraging trainees to engage in collaborative research across at least two different laboratories. Both programs meet significant public health needs: the skills that trainees acquire are essential in future biomedical careers as they join teams that combine diverse backgrounds to meet a common goal in research, development, and ultimately commercialization.