Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus
Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus
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DOI：
10.1007/s10552-011-9741-8
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发表时间：
2011-05-01
影响因子：
2.3
通讯作者：
McGlynn, Katherine A.
中科院分区：
文献类型：
--
作者：
Trabert, Britton;Longnecker, Matthew P.;McGlynn, Katherine A.
目的宫内类固醇激素暴露可能与睾丸生殖细胞瘤（TGCT）等癌症的发生有关。为了确定胎盘特征是否是母体生物标志物水平的良好替代指标，我们评估了TGCT风险较高（白人，n = 150）和较低（黑人，n = 150）儿子的母亲的相关性。协会与出生体重也examined.Methods所有的母亲，参与围产期合作项目，是谁生下了男性单胎的pregnancy。使用线性回归评估胎盘重量和胎盘厚度与妊娠晚期生物标志物水平之间的关联。结果白人胎盘重量与甲胎蛋白（AFP）、性激素结合球蛋白（SHBG）、睾酮、雌二醇、雌三醇呈正相关，黑人与AFP、雌三醇呈正相关。胎盘厚度与任何生物标志物无关。调整胎盘重量后，出生体重与任何生物标志物无关。结论在这些数据中，胎盘重量与晚期妊娠生物标志物水平适度相关，但是，它似乎是一个更好的替代晚期妊娠生物标志物水平比出生体重。胎盘厚度作为生物标志物水平的替代指标的效用有限。
Objective In utero exposure to steroid hormones may be related to risk of some cancers such as testicular germ cell tumors (TGCT). To determine whether placental characteristics are good surrogate measures of maternal biomarker levels, we evaluated the correlations in mothers of sons at higher (whites, n = 150) and lower (blacks, n = 150) risk of TGCT. Associations with birth weight were also examined.Methods All mothers, participants in the Collaborative Perinatal Project, were primigravidas who gave birth to male singletons. Associations between placental weight and placental thickness and third-trimester biomarker levels were evaluated using linear regression. Partial correlation coefficients for placental characteristics and birth weight were also estimated.Results Placental weight was positively correlated with alpha-fetoprotein (AFP), sex hormone-binding globulin (SHBG), testosterone, estradiol and estriol in whites, and AFP and estriol in blacks. Placental thickness was not associated with any biomarker. After adjustment for placental weight, birth weight was not correlated with any biomarker.Conclusions In these data, placental weight was modestly correlated with third-trimester biomarker level; however, it appeared to be a better surrogate for third-trimester biomarker level than birth weight. Placental thickness had limited utility as a surrogate measure for biomarker levels.