The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection
The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection
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DOI：
10.1093/embo-reports/kvd073
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发表时间：
2000-10-01
期刊：
影响因子：
7.7
通讯作者：
Lemaitre, B
中科院分区：
文献类型：
--
作者：
Leulier, F;Rodriguez, A;Lemaitre, B
果蝇先天免疫系统区分病原体，并通过不同的信号级联诱导特异性抗菌肽编码基因的表达来应答。真菌感染通过Toll途径激活NF-κ B样转录因子，这也调节哺乳动物的先天免疫应答。然而，介导抗菌防御的途径还不太明确。我们已经在半胱天冬酶编码基因dredd中分离出功能缺失突变，它阻断了所有编码具有抗菌活性的肽的基因的表达。这些突变也使果蝇对革兰氏阴性菌的感染高度敏感。我们的研究结果表明，Dredd调节抗菌肽基因的表达，我们提出，Dredd，免疫缺陷和P105样rel蛋白Relish定义了抵抗革兰氏阴性菌感染所需的途径。
The Drosophila innate immune system discriminates between pathogens and responds by inducing the expression of specific antimicrobial peptide-encoding genes through distinct signaling cascades. Fungal infection activates NF-kappaB-like transcription factors via the Toll pathway, which also regulates innate immune responses in mammals. The pathways that mediate antibacterial defenses, however, are less defined. We have isolated loss-of- function mutations in the caspase encoding gene dredd, which block the expression of all genes that code for peptides with antibacterial activity. These mutations also render flies highly susceptible to infection by Gram-negative bacteria. Our results demonstrate that Dredd regulates antibacterial peptide gene expression, and we propose that Dredd, Immune Deficiency and the P105-like rel protein Relish define a pathway that is required to resist Gram-negative bacterial infections.