Kinesin motors driven microtubule swarming triggered by UV light
Kinesin motors driven microtubule swarming triggered by UV light
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DOI：
10.1038/s41428-022-00693-1
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发表时间：
2022-08
期刊：
影响因子：
2.8
通讯作者：
Satsuki Ishii;Mousumi Akter-;Keiji Murayama;A. Kabir;H. Asanuma;K. Sada;A. Kakugo
中科院分区：
文献类型：
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作者：
Satsuki Ishii;Mousumi Akter-;Keiji Murayama;A. Kabir;H. Asanuma;K. Sada;A. Kakugo
我们报道了由生物分子运动驱动蛋白驱动的微管群集和在紫外光和可见光照射下微管群集的解离。我们在单链DNA的主链上引入了对叔丁基取代的偶氮苯，这是一种光响应分子，具有光开关的功能。由于光开关，DNA结合的微管的群集控制和可逆的调节微管群集后，以重复的方式实现交替照射紫外线和可见光。这种微管的可逆群集可以为设计具有多任务能力的复杂群集系统提供新的机会，加速分子机器的发展。
We report the swarming of microtubules driven by the biomolecular motor kinesin and dissociation of microtubule swarms under UV and visible light irradiation, respectively. We introducedpara tert-butyl-substituted azobenzene, a photoresponsive molecule, to the backbone of single strand DNA, which functions as a photoswitch. Due to the photoswitch, the swarming of DNA-conjugated microtubules was controlled and reversible regulation of microtubule swarming was achieved in a repeated manner upon alternate irradiation with UV and visible light. This reversible swarming of microtubules could provide new opportunities for designing complex swarming systems with the ability of multitasking, expediting the development of molecular machines.