Kidney Transplantation for Primary Focal Segmental Glomerulosclerosis: Outcomes and Response to Therapy for Recurrence
Kidney Transplantation for Primary Focal Segmental Glomerulosclerosis: Outcomes and Response to Therapy for Recurrence
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DOI：
10.1097/tp.0b013e31819f12be
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发表时间：
2009-04-27
期刊：
影响因子：
6.2
通讯作者：
Griffin, Matthew D.
中科院分区：
文献类型：
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作者：
Hickson, LaTonya J.;Gera, Manish;Griffin, Matthew D.
背景。对于原发性局灶节段性肾小球硬化（FSGS）的一部分成人和儿童，肾移植（KTx）后会复发蛋白尿和肾功能障碍。预测复发和对血浆置换（PP）或其他干预措施的反应仍然存在问题。在1573名KTx接受者中测定了FSGS患者的患病率、复发率、结局和治疗反应。虽然5.0%的患者被诊断为FSGS，但只有1.9% （n=30）的患者符合原发性FSGS的严格诊断标准，包括活检证实的FSGS、缺乏继发因素、阴性家族史和10年内进展为终末期肾脏疾病。其中47%的患者有复发性FSGS，而不符合严格标准的患者中有8% (P
Background. For a subset of adults and children with primary focal segmental glomerulosclerosis (FSGS), proteinuria and renal dysfunction recur after kidney transplantation (KTx). Predicting recurrence and response to plasmapheresis (PP) or other interventions remains problematic.Methods. The prevalence, recurrence rate, outcomes, and treatment responses of patients with FSGS were determined among 1573 KTx recipients. Although 5.0% carried some diagnosis of FSGS, only 1.9% (n=30) met strict diagnostic criteria for primary FSGS including biopsy-proven FSGS, lack of secondary factors, negative family history, and progression to end-stage renal disease within 10 years.Results. Of these, 47% had recurrent FSGS compared with 8% of those not meeting strict criteria (P