Natural Nrf2 Modulators for Skin Protection.
Natural Nrf2 Modulators for Skin Protection.
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DOI：
10.3390/antiox9090812
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发表时间：
2020-09-01
期刊：
影响因子：
--
通讯作者：
Boo YC
中科院分区：
文献类型：
--
作者：
Boo YC
自从抗氧化反应元件（ARE）和核因子红细胞2相关因子2（Nrf 2）被发现以来，这一领域的研究在过去的几十年中得到了显著的发展，Nrf 2介导的途径在细胞防御机制中占据了中心地位。通过直接激活Nrf 2诱导II期代谢/抗氧化酶通常是预防退行性疾病的有希望的策略，但应考虑该策略的黑暗面，因为Nrf 2激活可以增强癌细胞的存活。本文就Nrf 2的发现历史和Nrf 2介导的信号通路的调控机制进行综述，重点介绍了Nrf 2的相互作用蛋白和翻译后修饰。此外，我们讨论了最新的研究，研究了各种天然Nrf 2调节剂在皮肤中的保护作用，考虑到它们的皮肤病学和化妆品应用。研究尽可能按照研究时间顺序进行回顾，以帮助理解在当时的情况下如何以及为什么进行这些研究。我们希望这篇综述能为新进入这一领域的研究人员提供科学依据，从而为开展更深入的研究奠定基础。
Since the discovery of antioxidant responsive elements (ARE), which are commonly found in the promoter of the Phase II metabolism/antioxidant enzymes, and nuclear factor erythroid 2-related factor 2 (Nrf2), the transcription factor that binds to ARE, the study conducted in this field has expanded remarkably over the decades, and the Nrf2-mediated pathway is now recognized to occupy a central position in cell defense mechanisms. Induction of the Phase II metabolism/antioxidant enzymes through direct activation of Nrf2 can be a promising strategy for preventing degenerative diseases in general, but a dark side of this strategy should be considered, as Nrf2 activation can enhance the survival of cancer cells. In this review, we discuss the historical discovery of Nrf2 and the regulatory mechanism of the Nrf2-mediated pathway, focusing on the interacting proteins and post-translational modifications. In addition, we discuss the latest studies that examined various natural Nrf2 modulators for the protective roles in the skin, in consideration of their dermatological and cosmetic applications. Studies are reviewed in the order of time of research as much as possible, to help understand how and why such studies were conducted under the circumstances of that time. We hope that this review can serve as a steppingstone in conducting more advanced research by providing a scientific basis for researchers newly entering this field.
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影响因子：
5.3
作者：
Derjuga, A;Gourley, TS;Blank, V
通讯作者：
Blank, V
DOI：
10.1073/pnas.172398899
发表时间：
2002-09-03
影响因子：
11.1
作者：
Dinkova-Kostova, AT;Holtzclaw, WD;Talalay, P
通讯作者：
Talalay, P
影响因子：
5.2
作者：
Ding, Min;Zhao, Jinshun;Shi, Xianglin
通讯作者：
Shi, Xianglin
DOI：
10.1089/dna.1.1989.8.399
发表时间：
1989-07-01
期刊：
DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY
影响因子：
--
作者：
DANIEL, V;SHARON, R;BENSIMON, A
通讯作者：
BENSIMON, A
影响因子：
8
作者：
Chowdhry, S.;Zhang, Y.;McMahon, M.;Sutherland, C.;Cuadrado, A.;Hayes, J. D.
通讯作者：
Hayes, J. D.