Acute nonsteroidal anti-inflammatory drug-induced colitis.
Acute nonsteroidal anti-inflammatory drug-induced colitis.
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DOI：
10.4103/0974-2700.120389
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Tonolini M
中科院分区：
文献类型：
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作者：
Tonolini M
由于对肠粘膜的直接毒性，非甾体抗炎药（NSAID）诱导的结肠炎是一种被低估的潜在严重疾病。腹部平片和多探测器计算机断层扫描可确定右侧急性结肠炎伴相关结肠周围炎症，沿降结肠和乙状结肠的变化沿着逐渐减少，直肠保留，与NSAID结肠炎的假设发病机制一致。提高对这种情况的认识应通过预防和早期识别来降低发病率。高度的临床怀疑和适当的患者询问，加上一致的仪器结果，阴性生化和粪便检查，应有助于医生不要错过这一重要的诊断。
Resulting from direct toxicity on the bowel mucosa, nonsteroidal anti-inflammatory drug (NSAID)-induced colitis is an underestimated although potentially serious condition. Plain abdominal radiographs and multidetector computed tomography allow to identify a right-sided acute colitis with associated pericolonic inflammation, progressively diminished changes along the descending and sigmoid colon, and rectal sparing, consistent with the hypothesized pathogenesis of NSAID colitis. Increased awareness of this condition should reduce morbidity through both prevention and early recognition. High clinical suspicion and appropriate patient questioning, together with consistent instrumental findings, negative biochemistry, and stool investigations should help physicians not to miss this important diagnosis.