Directional extraction and penetration of phosphorene nanosheets to cell membranes
Directional extraction and penetration of phosphorene nanosheets to cell membranes
复制标题
磷烯纳米片定向萃取并渗透至细胞膜
DOI：
10.1039/c9nr09577b
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发表时间：
2020
期刊：
影响因子：
6.7
通讯作者：
Zhou Ruhong
中科院分区：
文献类型：
--
作者：
Zhang Wei;Chen Yezhe;Tien Huynh;Yang Yunqiu;Yang Xianqing;Zhou Ruhong
近年来，具有褶皱表面形貌的新型二维纳米材料亚磷烯被证明具有细胞毒性，但其潜在的分子机制尚不清楚。在这里，我们利用大规模的分子动力学模拟表明，由于磷烯和脂分子之间强烈的分散相互作用，磷烯纳米片可以穿透细胞膜并从细胞膜中提取大量的磷脂，这将降低细胞的存活率。由于磷烯纳米片独特的褶皱结构，提取的磷脂分子沿磷烯纳米片的褶皱方向排列。我们的结果还表明，细小的磷烯纳米片以特定的方向进入细胞膜，这取决于磷烯的大小、表面形貌和膜的厚度。这些发现可能有助于理解磷烯的细胞毒性，并有助于磷烯未来潜在的生物医学应用，如生物传感器和抗菌剂。
Recently, phosphorene, a novel two-dimensional nanomaterial with a puckered surface morphology, was shown to exhibit cytotoxicity, but its underlying molecular mechanisms remain unknown. Herein, using large scale molecular dynamics simulations, we show that phosphorene nanosheets can penetrate into and extract large amounts of phospholipids from the cell membranes due to the strong dispersion interaction between phosphorene and lipid molecules, which would reduce cell viability. The extracted phospholipid molecules are aligned along the wrinkle direction of the phosphorene nanosheet because of its unique puckered structure. Our results also reveal that small phosphorene nanosheets penetrate into the cell membrane in a specific direction which is determined by the size and surface topography of phosphorene and the thickness of the membrane. These findings might shed light on understanding phosphorene's cytotoxicity and would be helpful for the future potential biomedical applications of phosphorene, such as biosensors and antibacterial agents.