Alternans in atria: Mechanisms and clinical relevance.

Alternans in atria: Mechanisms and clinical relevance.
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DOI:
10.1016/j.medici.2017.04.004
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发表时间:
2017
期刊:
Medicina (Kaunas, Lithuania)
影响因子:
--
通讯作者:
Blatter LA
Blatter LA
中科院分区:
其他
文献类型:
--
作者:
Kanaporis G;Blatter LA

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心房颤动是最常见的持续性心律失常,其患病率随着人口老龄化而迅速上升。心脏电交替(cardiac alternans)是指在恒定刺激速率下,心脏收缩力、动作电位(AP)时程和细胞内Ca 2+释放的周期性搏动交替,与室性心律失常的发生有关。最近的临床数据也提供了有力的证据表明交替糖在心房肌的发生中起着核心作用。本文的目的是审查的机制,负责复极交替,并有助于过渡到空间一致的交替,更embrammogenic空间不一致的交替在心房。
Atrial fibrillation is the most common sustained arrhythmia and its prevalence is rapidly rising with the aging of the population. Cardiac alternans, defined as cyclic beat-to-beat alternations in contraction force, action potential (AP) duration and intracellular Ca2+ release at constant stimulation rate, has been associated with the development of ventricular arrhythmias. Recent clinical data also provide strong evidence that alternans plays a central role in arrhythmogenesis in atria. The aim of this article is to review the mechanisms that are responsible for repolarization alternans and contribute to the transition from spatially concordant alternans to the more arrhythmogenic spatially discordant alternans in atria.
DOI: 10.1016/j.hrthm.2010.04.008
发表时间: 2010-08
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