Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism
Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism
复制标题
从氧化铁纳米颗粒的内在拮抗作用解读其活性生物相容性
DOI：
10.1007/s12274-017-1905-8
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发表时间：
2018
期刊：
影响因子：
9.9
通讯作者：
Fan Chunhai
中科院分区：
文献类型：
--
作者：
Wang Lu;Wang Zejun;Li Xiaoming;Zhang Yi;Yin Min;Li Jiang;Song Haiyun;Shi Jiye;Ling Daishun;Wang Lihua;Chen Nan;Fan Chunhai
Magnetite nanoparticles (Fe3O4NPs) are a well proven biocompatible nanomaterial, which hold great promise in various biomedical applications. Interestingly, unlike conventional biocompatible materials (e.g., polyethylene glycol (PEG)) that are chemically and biologically inert in nature, Fe3O4NPs are known to be catalytically active and exhibit prominent physiological effects. Herein, we report an “active”, dynamic equilibrium mechanism for maintaining the cellular amenity of Fe3O4NPs. We examined the effects of two types of iron oxide (magnetite and hematite) NPs in rat pheochromocytoma (PC12) cells and found that both induced stress responses. However, only Fe2O3NPs caused significant programmed cell death; whereas Fe3O4NPs are amenable to cells. We found that intrinsic catalase-like activity of Fe3O4NPs antagonized the accumulation of toxic reactive oxygen species (ROS) induced by themselves, and thereby modulated the extent of cellular oxidative stress, autophagic activity, and programmed cell death. In line with this observation, we effectively reversed severe autophagy and cell death caused by Fe2O3NPs via co-treatment with natural catalase. This study not only deciphers the distinct intrinsic antagonism of Fe3O4NPs, but opens new routes to designing biocompatible theranostic nanoparticles with novel mechanisms.
