Effects of PPARα, γ and δ haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study
Effects of PPARα, γ and δ haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study
复制标题
DOI：
10.1097/00008571-200401000-00007
复制
发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Marian, AJ
中科院分区：
文献类型：
--
作者：
Chen, S;Tsybouleva, N;Marian, AJ
过氧化物酶体增殖物激活受体（PPARs）α、δ和γ是调节脂肪酸生物合成的核转录因子。我们的目的是确定过氧化物酶体增殖物激活受体单倍型对生化，血管造影，临床表型及其对氟伐他汀治疗反应的影响。我们对372名脂蛋白和冠状动脉粥样硬化研究受试者进行了基因分型，检测了7个单核苷酸多态性（SNP），分别为：PPARalpha（-35089A>C，484 C>G），delta（-4401CC）和gamma（34 C>G，25506 C>T，161 C
Peroxisome proliferator-activated receptors (PPARs) alpha, delta and gamma are nuclear transcription factors that regulate fatty acid biosynthesis. Our objectives were to determine the effects of PPAR haplotypes on biochemical, angiographic, clinical phenotypes and their responses to treatment with fluvastatin. We genotyped 372 Lipoprotein and Coronary Atherosclerosis Study subjects for seven single nucleotide polymorphisms (SNPs) in PPARalpha (-35 089A>C, 484C>G), delta (-4401 CC) and gamma (34C>G, 25 506C>T, 161 C